189153-16-0Relevant academic research and scientific papers
Aminopyrimidines with high affinity for both serotonin and dopamine receptors
Wustrow, David,Belliotti, Thomas,Glase, Shelly,Kesten, Suzanne Ross,Johnson, Don,Colbry, Norman,Rubin, Ronald,Blackburn, Anthony,Akunne, Hyacinth,Corbin, Ann,Duff Davis,Georgic, Lynn,Whetzel, Steven,Zoski, Kim,Heffner, Thomas,Pugsley, Thomas,Wise, Lawrence
, p. 760 - 771 (2007/10/03)
A series of {4-[2-(4-arylpiperazin-1-yl)alkyl]cyclohexyl}pyrimidin-2- ylamines was prepared and found to have receptor binding affinity for D2 and D3 dopamine (DA) receptors and serotonin 5-HT1A receptors. The structural contributions to D2/D3 and 5-HT1A
Novel cyclohexyl amides as potent and selective D3 dopamine receptor ligands
Belliotti, Thomas R.,Kesten, Suzanne R.,Rubin, John R.,Wustrow, David J.,Georgic, Lynn M.,Zoski, Kim T.,Akunne, Hyacinth C.,Wise, Lawrence D.
, p. 2403 - 2408 (2007/10/03)
The dopamine D3 receptor is an attractive target for the treatment of schizophrenia. We identified PD137557 (V) as a ligand for the D2 receptor and desired to prepare a selective D3 compound. SAR studies involving different amides and different phenyl piperazines have led to the discovery of 8a and 8c as selective D3 receptor ligands.
