189187-29-9Relevant academic research and scientific papers
First General Synthesis of (p-Nitroaryl)diarylmethanes via Vicarious Nucleophilic Substitution of Hydrogen
Katritzky, Alan R.,Toader, Dorin
, p. 4137 - 4141 (1997)
A general regiospecific method for the synthesis of (p-nitroaryl)diarylmethanes has been developed starting from diarylmethanols and 2- and/or 3-substituted nitrobenzenes. This utilizes the quantitative condensation between benzotriazole and diarylmethanols under acidic catalysis and in the presence of perfluorocarbon fluids, followed by vicarious nucleophilic substitution of the resulting diarylmethylbenzotriazoles upon nitrobenzenes in moderate to high yield, Oxidative nucleophilic substitution of hydrogen is observed as a side process. These vicarious nucleophilic substitutions complement Friedel-Crafts reactions for the synthesis of triarylmethanes.
Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para -nitrogen substituted isocombretastatins
Jiménez, Carmen,Ellahioui, Younes,álvarez, Raquel,Aramburu, Laura,Riesco, Alejandra,González, Myriam,Vicente, Alba,Dahdouh, Abdelaziz,Ibn Mansour, Ahmed,Jiménez, Carlos,Martín, Diego,Sarmiento, Rogelio G.,Medarde, Manuel,Caballero, Esther,Peláez, Rafael
, p. 210 - 222 (2015)
We have synthesized and assayed dimethylaminophenyl, pyrrolidin-1-ylphenyl and carbazole containing phenstatins and isocombretastatins as analogues of the highly potent indoleisocombretastatins with extended or reduced ring sizes. This is an attempt to ex
Disproportionation reaction of diarylmethylisopropyl ethers: a versatile access to diarylmethanes from diarylcarbinols speeded up by the use of microwave irradiation
L'Hermite, Nathalie,Giraud, Anne,Provot, Olivier,Peyrat, Jean-Fran?ois,Alami, Mouad,Brion, Jean-Daniel
, p. 11994 - 12002 (2007/10/03)
An efficient synthesis of diarylmethanes under classical thermal conditions and under microwave heating is described from diarylcarbinols via a new disproportionation reaction. The key step involves a selective hydride transfer of isopropyl ether intermed
