189197-69-1

Basic information

• Product Name: RO 48-8071
• Synonyms: Aids163155;Aids-163155;Methanone, (4-bromophenyl)[2-fluoro-4-[[6-(methyl-2-propenylamino)hexyl]oxy]phenyl]-,(2E)-2-butenedioate;(4-((6-(allyl(methyl)amino)hexyl)oxy)-2-fluorophenyl)(4-bromophenyl)methanone fumarate Ro48-8071;Ro 48-8071 fumarate salt;(4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone (2E)-2-butenedioate (1:1);OSC Inhibitor, Ro 48-8071
• CAS NO: 189197-69-1
• Molecular Formula: C23H27BrFNO2.C4H4O4
• Molecular Weight: 564.45
• Product Categories: Inhibitors
• Mol File: 189197-69-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 90-92.7 °C
• Boiling Point: 522.8°Cat760mmHg
• Flash Point: 270°C
• Appearance: white/solid
• Density: 1.235g/cm³
• Storage Temp.: 2-8°C
• Solubility: H2O: >5 mg/mL at ~60 °C
• CAS DataBase Reference: RO 48-8071(CAS DataBase Reference)
• NIST Chemistry Reference: RO 48-8071(189197-69-1)
• EPA Substance Registry System: RO 48-8071(189197-69-1)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 189197-69-1(Hazardous Substances Data)

Usage

Definition

ChEBI: A fumarate salt obtained by combining Ro 48-8071 with one molar equivalent of fumaric acid. An inhibitor of lanosterol synthase.

Upstream product

• 161581-99-3 (4-bromophenyl)-(2'-fluoro-4'-hydroxyphenyl)-methanone 
• 456-49-5 1-fluoro-3-methoxybenzene 
• 586-75-4 4-chlorobenzoyl chloride 
• 161581-95-9 (4-bromo-phenyl)-(2-fluoro-4-methoxy-phenyl)-methanone 
• 110-17-8 (2E)-but-2-enedioic acid 
• 161582-11-2 [4-[6-(allyl-methyl-amino)-hexyloxy]-2-fluoro-phenyl]-(4-bromo-phenyl)-methanone 
• 629-03-8 1 ,6-dibromohexane 

Relevant articles and documents

INDUCTION OF ESTROGEN RECEPTOR BETA BY CHOLESTEROL BIOSYNTHESIS INHIBITORS AND METHODS OF TREATMENT OF CANCER

Disclosed herein are methods and compositions related to the discovery that cholesterol inhibitors induce the anti-proliferative protein, estrogen receptor beta (ERβ), in both ERα- positive and ERα-negative breast cancer cell lines, including triple negat