1892-22-4

Basic information

• Product Name: 3-amino-2-Piperidinone
• Synonyms: 3-amino-2-Piperidinone;3-Amino-2-piperidone;3-aminopiperidin-2-one(SALTDATA: HCl);2-Amino-delta-Valerolactam;3-Amino-2-piperidinon;Ornithine lactam
• CAS NO: 1892-22-4
• Molecular Formula: C₅H₁₀N₂O
• Molecular Weight: 114.15
• Mol File: 1892-22-4.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 307.5 °C at 760 mmHg
• Flash Point: 139.8 °C
• Appearance: /
• Density: 1.071 g/cm³
• Vapor Pressure: 0.000723mmHg at 25°C
• Refractive Index: 1.476
• Storage Temp.: -20°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 16.00±0.40(Predicted)
• CAS DataBase Reference: 3-amino-2-Piperidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-2-Piperidinone(1892-22-4)
• EPA Substance Registry System: 3-amino-2-Piperidinone(1892-22-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1892-22-4(Hazardous Substances Data)

Usage

Chemical Properties

Slightly pale yellow to yellow crystal or powder

Uses

3-Aminopiperidin-2-one (>90%) can be used as a biomarker to diagnose the silent phase of Alzeihmer’s disease.

InChI:InChI=1/C5H10N2O/c6-4-2-1-3-7-5(4)8/h4H,1-3,6H2,(H,7,8)/t4-/m1/s1

Upstream product

• 1069-31-4 DL-ornithine hydrochloride 
• 16682-12-5 D-ornithine hydrochloride 
• 138377-80-7 3-aminopiperidin-2-one hydrochloride 
• 261522-14-9 ornithine methyl ester hydrochloride 
• 3184-13-2 L-ornithine hydrochloride 
• 34294-79-6 (S)-(-)-3-aminopiperidin-2-one 
• 1069-31-4 L-ornithine hydochloride 
• 81084-75-5 ornithine methyl ester 

Downstream Products

• 84772-30-5 3-(2'-aminobenzoyl)aminopiperidin-2-one 
• 25219-59-4 3-methoxy-piperidin-2-one 
• 19365-08-3 3-hydroxypiperidin-2-one 
• 463362-71-2 3-iso-propoxy-piperidin-2-one 
• 53031-80-4 3-benzylidene-piperidin-2-one 
• 3328-28-7 N-(2'-oxopiperidin-3'-yl)benzamide 
• 1422128-64-0 3-{[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]amino}piperidin-2-one 

Relevant articles and documents

PROTAC-mediated crosstalk between E3 ligases

Small-molecule heterobifunctional degraders can effectively control protein levels and are useful research tools. We assembled proteolysis targeting chimeras (PROTACs) from a cereblon (CRBN) and a von-Hippel-Lindau (VHL) ligase ligand and demonstrated a PROTAC-induced heterodimerization of the two E3 ligases leading to unidirectional and efficient degradation of CRBN.

NITROGEN-CONTAINING HETEROCYCLIC COMPOUND

The present invention provides a novel compound having a superior activity as an ERR-alpha modulator and useful as an agent for the prophylaxis or treatment of ERR-alpha associated diseases. The present invention relates to a compound represented by the formula (1) wherein each symbol is as defined in the specification, or a salt thereof

QUINAZOLINE DERIVATIVES

A quinazoline derivative of the formula (I) wherein: R1, R2, R3, R3a, R4, R5, R5a R6, R7, a, m and p are as defined in the description. Also claimed are pharmaceutical compositions containing the quinazoline derivative, the use of the quinazoline derivatives as medicaments and processes for the preparation of the quinazoline derivative. The quinazoline derivatives of formula (I), are useful in the treatment of hyperproliferative disorders such as a cancer.