18920-63-3

Basic information

• Product Name: vitamin E
• Synonyms: vitamin E
• CAS NO: 18920-63-3
• Molecular Weight: 430.715
• Mol File: 18920-63-3.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: vitamin E(CAS DataBase Reference)
• NIST Chemistry Reference: vitamin E(18920-63-3)
• EPA Substance Registry System: vitamin E(18920-63-3)

Safety Data

• Hazardous Substances Data: 18920-63-3(Hazardous Substances Data)

Upstream product

• 59-02-9 vitamin E 
• 110-82-7 cyclohexane 
• 10191-41-0 (+/-)-α-tocopherol 
• 197297-77-1 4-(2,5-dimethoxy-3,4,6-trimethylphenyl)butan-2-one 
• 131426-03-4 1-iodo-2,5-bis(methoxy)-3,4,6-trimethylbenzene 
• 16825-16-4 (6R,10R)-6,10,14-trimethylpentadecan-2-one 
• 150-86-7 phytol 
• 82299-54-5 2-(2,5-dimethoxy-3,4,6-trimethylphenyl)ethylmagnesium bromide 
• 4537-09-1 1,4-dimethoxy-2,3,5-trimethyl-benzene 
• 114341-71-8 (4R,8R)-1-Bromo-4,8,12-trimethyltridecane 
• 87247-35-6 (4R,8R)-4,8,12-trimethyltridecan-1-ol 
• 188416-16-2 (R)-(+)-6-benzyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-ylmethanol 
• 474255-79-3 (3R,7S)-3,7,11-trimethyl-10-dodecenal 

Downstream Products

• 16676-75-8 DL-α-tocopherol nicotinate 
• 1406-70-8 (all-rac)-α-tocopheryl acetate 
• 54165-54-7 2S,4'R,8'R-α-tocopheryl acetate 
• 87291-70-1 DL-α-Tocopheryl phosphate dianilide 

Relevant articles and documents

Highly stereoselective construction of the C2 stereocentre of α-tocopherol (Vitamin E) by asymmetric addition of Grignard reagents to ketones

Tertiary alcohol precursors of both C2 diastereoisomers of α-tocopherol were prepared in three ways by our recently reported asymmetric Grignard synthesis. The versatility of Grignard chemistry inherent in its three-way disconnection was exploited to allow the synthesis of three product grades: 77:23 dr (5 steps), 81:19 dr (5 steps) and 96:4 dr (7 steps, one gram scale) from readily available and abundant starting materials. The products were converted to their respective α-tocopherols in 3 steps, which allowed a definitive re-assignment of their absolute configurations.

Screening of a virtual mirror-image library of natural products

We established a facile access to an unexplored mirror-image library of chiral natural product derivatives using d-protein technology. In this process, two chemical syntheses of mirror-image substances including a target protein and hit compound(s) allow the lead discovery from a virtual mirror-image library without the synthesis of numerous mirror-image compounds.

Process of separating chiral isomers of chroman compounds and their derivatives and precursors

The present invention relates to a process of separating chiral isomers of chroman compounds, particularly tocopherols and tocotrienols as well as the esters and intermediates thereof. It has been found that this process allows a separation of the desired isomer with a higher yield and enables the use of the non-desired isomers in a very efficient way. Said process is particularly useful when implemented in an industrial process. Furthermore, it has been found that this process allows using isomer mixtures as they result from traditional industrial synthesis.