189251-19-2

Upstream product

• 4146-04-7 DL-2-amino-1-pentanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 109-67-1 1-penten 
• 55962-05-5 4-methyl-N-[(E)-phenyl-λ³-iodanylidene]benzenesulfonamide 
• 760-78-1 2-aminopentanoic acid 

Downstream Products

• 260550-89-8 (-)-1-(benzofuran-2-yl)-2-propylaminopentane 
• 189251-22-7 N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-N-(1-propyl-hept-6-enyl)-benzenesulfonamide 
• 147363-82-4 epilachnene 

Relevant academic research and scientific papers

Efficient Aziridination of Olefins Catalyzed by a Unique Disilver(I) Compound

A unique disilver(I) compound is an efficient catalyst for aziridination of olefins. Copyright

Enantioselective synthesis and absolute configuration of (-)-1-(benzofuran-2-yl)-2-propylaminopentane, ((-)-BPAP), a highly potent and selective catecholaminergic activity enhancer

Enantioselective synthesis and absolute configuration of (-)-1-(benzofuran-2-yl)-2-propylaminopentane ((-)-BPAP), which is a highly potent and selective catecholaminergic activity enhancer (CAE) substance, are described. The synthetic approach consists of the coupling reaction of benzofuran with (R)-N-tosyl-2-propylazirizine or (R)-N-methoxy-N-methylnorvaliamide, followed by appropriate modifications of the resulting coupling products. As the results, (-)-BPAP turned out to have the R configuration, which was finally confirmed by X-ray crystallographic analysis.

Absolute configuration of insect-produced epilachnene

Samples of (X) and (S)-epilachnene [(5Z)-11-propyl-12-azacyclotetradec-5-en olide] were synthesized from (R) and (S)-norvaline. The diastereomeric α-methoxy-α-trifluoromethylphenylacetyl amides of these synthetic samples, prepared using (S) α-methoxy-α-trifluoromethylphenylacetyl chloride, were well resolved by gas chromatography. Analogous derivatization and gas chromatographic analysis of a sample of epilachnene from the pupal secretion of the coccinellid beetle, Epilachna varivestis, established that the natural product is (S)-epilachnene.