4146-04-7

Usage

Uses

Used in Pharmaceutical Industry:
D/L-NORVALINOL is used as a solvent for evaluating lyotropic liquid crystal mesophases of hexadecylpyridinium bromide (C16PyrBr) by cross-polarised optical microscopy (CPOM). This application is crucial in the development and analysis of drug delivery systems, as it helps researchers understand the behavior of these systems at the molecular level.
Used in Chemical Synthesis:
D/L-NORVALINOL can also be used as a starting material or intermediate in the synthesis of various pharmaceuticals and other chemicals. Its unique structure and functional groups make it a versatile building block for creating a wide range of compounds with different properties and applications.

InChI:InChI=1/C4H9N/c1-3-4-5-2/h3,5H,1,4H2,2H3

Upstream product

• 2899-90-3 2-nitro-pentan-1-ol 
• 516-06-3 D,L-valine 
• 760-78-1 2-aminopentanoic acid 
• 13893-43-1 ethyl 2-aminopentanoate 
• 10047-10-6 norvaline methyl ester hydrochloride 
• 132949-27-0 1-((S)-2-Methoxy-1-phenyl-ethoxymethyl)-butylamine 
• 132949-24-7 N-benzyloxy-1-((S)-2-methoxy-1-phenylethoxy)-4-penten-2-ylamine 

Downstream Products

• 16112-61-1 4-Propyl-oxazolidon-(2) 
• 69451-78-1 Nicotinic acid 2-[(pyridine-3-carbonyl)-amino]-pentyl ester 
• 137160-75-9 N-(1-Hydroxymethyl-butyl)-butyramide 
• 145842-46-2 (+/-)-2-(acetylamino)pentyl acetate 
• 4293-54-3 2-acetylaminopentan-1-ol 
• 189251-19-2 N-(p-toluenesulfonyl)-2-propylaziridine 
• 750592-65-5 (+/-)-N,N-dibenzyl-2-aminopentan-1-ol 
• 260550-89-8 (-)-1-(benzofuran-2-yl)-2-propylaminopentane 
• 147363-82-4 epilachnene 
• 189251-22-7 N-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-N-(1-propyl-hept-6-enyl)-benzenesulfonamide 

Relevant academic research and scientific papers

A catalyst-free, convenient construction of eight-membered [1,4]oxazocane-5,8-dione heterocycles from aminoethanols with divinyl succinate

A convenient protocol for the synthesis of [1,4]oxazocane-5,8-dione heterocycles by direct cyclization using 2-substituted aminoethanols and divinyl succinate without any catalysts and additives was established. This strategy is quite simple and effective to obtain eight-membered rings incorporating lactone and lactam functional groups. Georg Thieme Verlag Stuttgart.

Amino alcohol derivatives, method of producing said derivatives and medicaments containing them

Compounds of formula I in which R1denotes hydrogen or methyl R2denotes lower straight-chained or branched alkyl with 1 to 10 carbon atoms R3denotes hydrogen or lower alkyl n denotes 0-12 R4denotes alkyl, alkenyl or alkinyl with 6 to 24 carbon atoms, processes for the production thereof as well as pharmaceutical agents containing these compounds for the treatment of osteoporosis.

Enantioselective synthesis and absolute configuration of (-)-1-(benzofuran-2-yl)-2-propylaminopentane, ((-)-BPAP), a highly potent and selective catecholaminergic activity enhancer

Enantioselective synthesis and absolute configuration of (-)-1-(benzofuran-2-yl)-2-propylaminopentane ((-)-BPAP), which is a highly potent and selective catecholaminergic activity enhancer (CAE) substance, are described. The synthetic approach consists of the coupling reaction of benzofuran with (R)-N-tosyl-2-propylazirizine or (R)-N-methoxy-N-methylnorvaliamide, followed by appropriate modifications of the resulting coupling products. As the results, (-)-BPAP turned out to have the R configuration, which was finally confirmed by X-ray crystallographic analysis.

Diastereofacial Discrimination in the reaction of Chiral Alkoxymethyl Oxime Ethers with Allyl Metallic Reagents

Allyl Grignard reagent complexed with cerium trichloride added to chiral (E)-alkoxymethyl oxime ether, derived from (S)-2-methoxy-1-phenylethanol, to give the corresponding (S)-amine stereoselectively, while the imino addition of allyllithium occurred wit