189279-33-2Relevant articles and documents
Design and assembly of new nonviral RNAi delivery agents by microwave-assisted quaternization (MAQ) of tertiary amines
Ghosh, Animesh,Mukherjee, Koushik,Jiang, Xinpeng,Zhou, Ying,McCarroll, Joshua,Qu, James,Swain, Pamela M.,Baigude, Huricha,Rana, Tariq M.
, p. 1581 - 1587 (2010)
RNA interference (RNAi) is a gene-silencing phenomenon whereby double-stranded RNA (dsRNA) triggers the sequence-specific degradation of homologous mRNA. RNAi has been quickly and widely applied to discover gene functions and holds great potential to prov
CHEMICAL COMPOUNDS
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Page/Page column 40, (2012/02/15)
The present invention relates to compounds of Formula (I): and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit Bcl-2 and/or Bcl-XL activities and may be used for the treatment of cancer.
Formulations and methods for generating active cytofectin: polynucleotide transfection complexes
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, (2008/06/13)
In the generation of cytofectin:polynucleotide complexes for transfection of cells, formulations, counterions, and reaction conditions for maximizing the transfection include using a cationic amine compound that has the general structure: STR1 wherein Rs