189279-33-2Relevant academic research and scientific papers
Design and assembly of new nonviral RNAi delivery agents by microwave-assisted quaternization (MAQ) of tertiary amines
Ghosh, Animesh,Mukherjee, Koushik,Jiang, Xinpeng,Zhou, Ying,McCarroll, Joshua,Qu, James,Swain, Pamela M.,Baigude, Huricha,Rana, Tariq M.
, p. 1581 - 1587 (2010)
RNA interference (RNAi) is a gene-silencing phenomenon whereby double-stranded RNA (dsRNA) triggers the sequence-specific degradation of homologous mRNA. RNAi has been quickly and widely applied to discover gene functions and holds great potential to prov
Aminolysis of cyclic thioxocarbonate of (R,R)-di-tert-butyl tartrate: Efficient access to thio- and thiolcarbamates
Faissat, Ludovic,Chavis, Claude,Montero, Jean-Louis,Lucas, Marc
, p. 1253 - 1259 (2002)
Aminolysis of cyclic thioxocarbonates derived from (R,R)-dialkyl tartrates with secondary amines is described to afford efficiently thio- and thiolcarbamates in a fast and high yielding reaction. Their stereochemistry and mechanism of formation are discus
CHEMICAL COMPOUNDS
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Page/Page column 40, (2012/02/15)
The present invention relates to compounds of Formula (I): and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit Bcl-2 and/or Bcl-XL activities and may be used for the treatment of cancer.
METHODS AND COMPOSITIONS FOR THE EFFICIENT DELIVERY OF THERAPEUTIC AGENTS TO CELLS AND ANIMALS
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Page/Page column 59-60; 6/17, (2008/06/13)
The present invention provides methods of carrying out the safe and reliable preparation of lipids comprising quaternary amines. Such lipids are especially suited for introducing therapeutic agents into cells or organisms. In particular, the lipids of the invention are suitable for the efficient transfer of gene therapy agents into mammalian cells or organisms in a cell type specific or tissue specific manner.
Formulations and methods for generating active cytofectin: polynucleotide transfection complexes
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, (2008/06/13)
In the generation of cytofectin:polynucleotide complexes for transfection of cells, formulations, counterions, and reaction conditions for maximizing the transfection include using a cationic amine compound that has the general structure: STR1 wherein Rs
Polyfunctional cationic cytofectins, formulations and methods for generating active cytofectin: polynucleotide transfection complexes
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, (2008/06/13)
Amine containing compounds and their use in the generation of cytofectin:polynucleotide complexes for transfection of cells, formulations, counterions, and reaction conditions for maximizing the transfection include using cationic amine compounds that hav
