189283-51-0

Usage

Uses

Used in Organic Synthesis:
3,4-Difluoro-2-hydroxybenzoic acid serves as a key intermediate in organic synthesis, facilitating the creation of a variety of chemical compounds. Its presence of fluorine atoms and hydroxyl group enhances the reactivity and selectivity of the molecule, making it a valuable building block in the synthesis process.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 3,4-Difluoro-2-hydroxybenzoic acid is utilized as a precursor for the development of new drugs. Its unique structure allows for the design of molecules with specific therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Agrochemicals:
3,4-Difluoro-2-hydroxybenzoic acid also finds application in the agrochemical sector, where it is employed in the synthesis of pesticides and other agricultural chemicals. Its chemical properties enable the creation of effective compounds for crop protection and enhancement of agricultural yields.
Used in Material Science:
With potential applications in material science, 3,4-Difluoro-2-hydroxybenzoic acid is explored for its ability to contribute to the development of new materials with improved properties. Its structural characteristics can influence the physical and chemical attributes of the materials it is incorporated into.
Used as a Chemical Reaction Reagent:
3,4-Difluoro-2-hydroxybenzoic acid functions as a reagent in various chemical reactions, providing a means to achieve specific chemical transformations. Its participation in these reactions can lead to the formation of desired products with applications across different industries.
It is important to handle 3,4-Difluoro-2-hydroxybenzoic acid with care due to its potential hazards, such as harmful effects if swallowed or inhaled, and its irritating nature to the skin and eyes. Proper safety measures should be taken during its use to ensure the well-being of individuals and the environment.

Upstream product

• 124-38-9 carbon dioxide 
• 367-11-3 ortho-difluorobenzene 
• 875664-52-1 2-methoxy-3,4-difluorobenzoic acid 
• 80-73-9 1,3-dimethyl-2-imidazolidinone 
• 61079-72-9 2,3,4,-trifluorobenzoic acid 
• 6418-38-8 2,3-difluorophenol 

Downstream Products

• 509147-86-8 6,7-difluoro-1,3-benzoxazol-2(3H)-one 

Relevant academic research and scientific papers

TRICYCLIC INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF

The present application relates to compounds of Formula (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions with BCL6 BTB, such as cancer.

INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF

The present application relates to compounds of Formula I (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions with BCL6 BTB, such as cancer.

Polyfluorinated salicylic acid derivatives as analogs of known drugs: Synthesis, molecular docking and biological evaluation

We have developed the convenient methods for synthesis of polyfluorosalicylic acids and their derivatives. For the first time the biological properties of polyfluorosalicylates were investigated in vitro (permeability through the biological membranes, COX-1 inhibitory action) and in vivo (anti-inflammatory, analgesic activities, acute toxicity). Molecular docking of polyfluorinated salicylates confirmed in vitro and in vivo experiments.

A convenient and efficient approach to polyfluorosalicylic acids and their tuberculostatic activity

We have developed the practical method for polyfluorosalicylic acids synthesis via nucleophilic ortho-mono-substitution of fluorine atom with magnesium methoxide. We have managed to increase the yield of targeted polyfluorosalicylic acids from good to quantitative. We have studied the tuberculostatic activity of polyfluorosalicylic acids. It has been found that minimum inhibitory concentration (MIC) of compounds is from 0.7 to 6.5 μg/mL depending on the structure.

Design, synthesis and anticancer activity of functionalized spiro-quinolines with barbituric and thiobarbituric acids

A new series of spiro-quinoline compounds have been accomplished by the reaction of barbituric acid or thiobarbituric acid with derivatives of benzisoxazole-5-carbaldehyde or 2-substituted benzaldehyde. These compounds were evaluated for their in vitro cy

The regioexhaustive functionalization of difluorophenols and trifluorophenols through organometallic intermediates

2,4-Difluorophenol, 2,5-difluorophenol, 2,3-difluorophenol, 3,5-difluorophenol, 3,4-difluorophenol, 2,4,5-trifluorophenol and 2,3,4-trifluorophenol were converted into all 18 possible di- or trifluorinated hydroxybenzoic acids (1a-c, 4a-c, 9a-c, 12a,b, 14a-c, 17a,b, 18a,b), all of them new compounds. The phenolic hydrogen atom was replaced by a methoxymethyl or, less frequently, by a triisopropylsilyl group, which exerted an ortho activating or ortho shielding effect, respectively. Sites flanked by two electronegative substituents (fluorine, alkoxy) were deprotonated with particular ease. They had to be silenced by the reversible attachment of a metalation-blocking trimethylsilyl group or of a metalation-deflecting chlorine atom if the metal was to be introduced elsewhere. In all cases but one, the stage was thus set for an intramolecular competition between metalation at an oxygen-adjacent or a fluorine-adjacent site. It proved indeed possible to secure the desired regioflexibility in either way by relying on an appropriate substrate-reagent matching. This demonstrates once more the potential of the organometallic approach to diversity-oriented synthesis.

Regio-selective hydroxysubstitution of fluorobenzoic acid derivatives: Facile synthesis of fluorosalicylic acid derivatives

Ortho-substituted fluorine in 2,4-difluorobenzoic acid was found to be regio-selectively replaced to hydroxide by solid sodium hydroxide in 1,3-dimethyl-2-imidazolidinone, to afford 4-fluoro-2-hydroxybenzoic acid in high yield. Several multi-fluoro-substi

4-fluorosalicyclic acid derivative and process for production thereof

PCT No. PCT/JP97/03761 Sec. 371 Date Jun. 12, 1998 Sec. 102(e) Date Jun. 12, 1998 PCT Filed Oct. 17, 1997 PCT Pub. No. WO98/17620 PCT Pub. Date Apr. 30, 1998The present invention provides a 4-fluorosalicylic acid derivative represented by the following ge