189283-54-3

Usage

Uses

Used in Pharmaceutical Industry:
2,4-DIFLUORO-6-HYDROXY-BENZOIC ACID is used as an intermediate for the synthesis of various pharmaceuticals due to its unique chemical structure and properties. It plays a crucial role in the development of new drugs with improved therapeutic effects and reduced side effects.
Used in Agrochemical Industry:
In the agrochemical industry, 2,4-DIFLUORO-6-HYDROXY-BENZOIC ACID is utilized as an intermediate for the synthesis of various agrochemicals, including pesticides and herbicides. Its unique properties contribute to the development of more effective and environmentally friendly agrochemicals.
Used in Research and Development:
2,4-DIFLUORO-6-HYDROXY-BENZOIC ACID is employed in research and development for its potential applications in organic synthesis. Its unique chemical structure allows scientists to explore new synthetic pathways and create novel compounds with potential uses in various industries.
Used in Organic Synthesis:
As a valuable building block, 2,4-DIFLUORO-6-HYDROXY-BENZOIC ACID is used in organic synthesis to create new compounds with potential industrial and biological uses. Its unique properties enable the development of innovative materials and compounds with improved performance and functionality.

InChI:InChI=1/C7H4F2O3/c8-3-1-4(9)6(7(11)12)5(10)2-3/h1-2,10H,(H,11,12)

Upstream product

• 872-50-4 1-methyl-pyrrolidin-2-one 
• 28314-80-9 2,4,6-trifluorobenzoic acid 
• 2713-34-0 3,5-difluorophenol 
• 124-38-9 carbon dioxide 
• 749230-20-4 1,3-difluoro-5-(methoxymethoxy)benzene 
• 749230-46-4 [2,6-difluoro-4-(methoxymethoxy)phenyl]trimethylsilane 

Relevant academic research and scientific papers

The regioexhaustive functionalization of difluorophenols and trifluorophenols through organometallic intermediates

2,4-Difluorophenol, 2,5-difluorophenol, 2,3-difluorophenol, 3,5-difluorophenol, 3,4-difluorophenol, 2,4,5-trifluorophenol and 2,3,4-trifluorophenol were converted into all 18 possible di- or trifluorinated hydroxybenzoic acids (1a-c, 4a-c, 9a-c, 12a,b, 14a-c, 17a,b, 18a,b), all of them new compounds. The phenolic hydrogen atom was replaced by a methoxymethyl or, less frequently, by a triisopropylsilyl group, which exerted an ortho activating or ortho shielding effect, respectively. Sites flanked by two electronegative substituents (fluorine, alkoxy) were deprotonated with particular ease. They had to be silenced by the reversible attachment of a metalation-blocking trimethylsilyl group or of a metalation-deflecting chlorine atom if the metal was to be introduced elsewhere. In all cases but one, the stage was thus set for an intramolecular competition between metalation at an oxygen-adjacent or a fluorine-adjacent site. It proved indeed possible to secure the desired regioflexibility in either way by relying on an appropriate substrate-reagent matching. This demonstrates once more the potential of the organometallic approach to diversity-oriented synthesis.

Regio-selective hydroxysubstitution of fluorobenzoic acid derivatives: Facile synthesis of fluorosalicylic acid derivatives

Ortho-substituted fluorine in 2,4-difluorobenzoic acid was found to be regio-selectively replaced to hydroxide by solid sodium hydroxide in 1,3-dimethyl-2-imidazolidinone, to afford 4-fluoro-2-hydroxybenzoic acid in high yield. Several multi-fluoro-substi

4-fluorosalicyclic acid derivative and process for production thereof

PCT No. PCT/JP97/03761 Sec. 371 Date Jun. 12, 1998 Sec. 102(e) Date Jun. 12, 1998 PCT Filed Oct. 17, 1997 PCT Pub. No. WO98/17620 PCT Pub. Date Apr. 30, 1998The present invention provides a 4-fluorosalicylic acid derivative represented by the following ge