189283-54-3

Basic information

• Product Name: 2,4-DIFLUORO-6-HYDROXY-BENZOIC ACID
• Synonyms: 2,4-DIFLUORO-6-HYDROXY-BENZOIC ACID;BENZOIC ACID, 2,4-DIFLUORO-6-HYDROXY-
• CAS NO: 189283-54-3
• Molecular Formula: C₇H₄F₂O₃
• Molecular Weight: 174.1
• Product Categories: pharmacetical
• Mol File: 189283-54-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 180.8-183.4 °C
• Boiling Point: 290.6 °C at 760 mmHg
• Flash Point: 129.5 °C
• Appearance: /
• Density: 1.6 g/cm³
• Vapor Pressure: 0.000944mmHg at 25°C
• Refractive Index: 1.557
• PKA: 2.52±0.25(Predicted)
• CAS DataBase Reference: 2,4-DIFLUORO-6-HYDROXY-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIFLUORO-6-HYDROXY-BENZOIC ACID(189283-54-3)
• EPA Substance Registry System: 2,4-DIFLUORO-6-HYDROXY-BENZOIC ACID(189283-54-3)

Safety Data

• Hazardous Substances Data: 189283-54-3(Hazardous Substances Data)

Usage

General Description

2,4-DIFLUORO-6-HYDROXY-BENZOIC ACID is a chemical compound with the molecular formula C7H4F2O3. It is a derivative of benzoic acid, containing two fluorine atoms and a hydroxyl group attached to the benzene ring. 2,4-DIFLUORO-6-HYDROXY-BENZOIC ACID is commonly used as an intermediate for the synthesis of various pharmaceuticals and agrochemicals. It is also used in research and development for its unique properties and potential applications in organic synthesis. 2,4-DIFLUORO-6-HYDROXY-BENZOIC ACID is a white crystalline solid with a melting point of 146-148°C and is sparingly soluble in water. Its chemical structure and properties make it a valuable building block for the creation of new compounds with potential industrial and biological uses.

InChI:InChI=1/C7H4F2O3/c8-3-1-4(9)6(7(11)12)5(10)2-3/h1-2,10H,(H,11,12)

Upstream product

• 124-38-9 carbon dioxide 
• 749230-46-4 [2,6-difluoro-4-(methoxymethoxy)phenyl]trimethylsilane 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 28314-80-9 2,4,6-trifluorobenzoic acid 
• 749230-20-4 1,3-difluoro-5-(methoxymethoxy)benzene 
• 2713-34-0 3,5-difluorophenol 

Relevant articles and documents

The regioexhaustive functionalization of difluorophenols and trifluorophenols through organometallic intermediates

2,4-Difluorophenol, 2,5-difluorophenol, 2,3-difluorophenol, 3,5-difluorophenol, 3,4-difluorophenol, 2,4,5-trifluorophenol and 2,3,4-trifluorophenol were converted into all 18 possible di- or trifluorinated hydroxybenzoic acids (1a-c, 4a-c, 9a-c, 12a,b, 14a-c, 17a,b, 18a,b), all of them new compounds. The phenolic hydrogen atom was replaced by a methoxymethyl or, less frequently, by a triisopropylsilyl group, which exerted an ortho activating or ortho shielding effect, respectively. Sites flanked by two electronegative substituents (fluorine, alkoxy) were deprotonated with particular ease. They had to be silenced by the reversible attachment of a metalation-blocking trimethylsilyl group or of a metalation-deflecting chlorine atom if the metal was to be introduced elsewhere. In all cases but one, the stage was thus set for an intramolecular competition between metalation at an oxygen-adjacent or a fluorine-adjacent site. It proved indeed possible to secure the desired regioflexibility in either way by relying on an appropriate substrate-reagent matching. This demonstrates once more the potential of the organometallic approach to diversity-oriented synthesis.

4-fluorosalicyclic acid derivative and process for production thereof

PCT No. PCT/JP97/03761 Sec. 371 Date Jun. 12, 1998 Sec. 102(e) Date Jun. 12, 1998 PCT Filed Oct. 17, 1997 PCT Pub. No. WO98/17620 PCT Pub. Date Apr. 30, 1998The present invention provides a 4-fluorosalicylic acid derivative represented by the following ge