18931-64-1Relevant articles and documents
2-aryl-6-polyfluoroalkyl-4-pyrones as promising rf-building-blocks: Synthesis and application for construction of fluorinated azaheterocycles
Mysik, Daria K.,Naumov, Nikita A.,Nigamatova, Diana I.,Obydennov, Dmitrii L.,Sosnovskikh, Vyacheslav Y.,Usachev, Sergey A.
, (2021)
A convenient and general method for the direct synthesis of 2-aryl-6-(trifluoromethyl)-4-pyrones and 2-aryl-5-bromo-6-(trifluoromethyl)-4-pyrones has been developed on the basis of one-pot oxidative cyclization of (E)-6-aryl-1,1,1-trifluorohex-5-ene-2,4-diones via a bromination/dehy-drobromination approach. This strategy was also applied for the preparation of 2-phenyl-6-polyfluoroalkyl-4-pyrones and their 5-bromo derivatives. Conditions of chemoselective enediones bromination were found and the key intermediates of the cyclization of bromo-derivatives to 4-pyrones were characterized. Synthetic application of the prepared 4-pyrones has been demonstrated for the construction of biologically important CF3-bearing azaheterocycles, such as pyra-zoles, pyridones, and triazoles.
Pyrazoles for the treatment of obesity and other CNS disorders
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Page/Page column 10, (2010/11/28)
This invention relates to compounds having pharmacological activity, to compositions containing these compounds, and to a method of treatment employing the compounds and compositions. More particularly, this invention concerns certain pyrazole derivatives, their salts and solvates. These compounds have H3 histamine receptor binding activity. This invention also relates to pharmaceutical compositions containing these compounds and to a method of treating disorders in which histamine H3 receptor modulation is beneficial.
detrifluoroacetylative diazo group transfer: (E)-1-Diazo-4-Phenyl-3-Buten-2-One: [3-Buten-2-one, 1-diazo-4-phenyl-]
Danheiser, Rick L.,Miller, Raymond F.,Brisbois, Ronald G.,Clark, Cameron,Martin, Stephen F.
, p. 134 - 134 (2017/09/16)
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