29170-03-4Relevant articles and documents
An Improved Method for the Synthesis of α-Diazo Ketones
Danheiser, Rick L.,Miller, Raymond F.,Brisbois, Ronald G.,Park, Saung Z.
, p. 1959 - 1964 (1990)
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One-step syntheses of substituted 2-pyrrolidinones and 3-pyrrolidinones from α,β-unsaturated diazoketones and amines. Application in the synthesis of barmumycin
Dias, Rafael M.P.,Momo, Patrícia B.,Burtoloso, Antonio C.B.
, p. 3720 - 3729 (2017/06/13)
A simple and one-pot way to prepare substituted 2- and 3-pyrrolidinones is described. The method uses unsaturated diazoketones (obtained from aldeydes in a single step) and amines, and provide an easy access to these important classes of nitrogen heterocycles. Furthermore, application of this methodology to the synthesis of the natural product barmumycin is achieved in 3 steps from these diazoketones.
A two-step synthesis of the bioprotective agent JP4-039 from N-Boc-l-leucinal
Bernardim, Barbara,Burtoloso, Antonio C.B.
, p. 3291 - 3296 (2014/05/06)
An expedited synthesis of the bioprotective agent JP4-039 is described from N-Boc-l-leucinal in 50% overall yield. The synthesis involves the use of an α,unsaturated diazoketone as the key intermediate, followed by a photochemical Wolff rearrangement in t
