18944-00-8

Basic information

• Product Name: N-methyl-valine hydrochloride
• Synonyms: N-Methyl-L-valine HCl
• CAS NO: 18944-00-8
• Molecular Formula: C₆H₁₃NO₂*ClH
• Molecular Weight: 167.63386
• Mol File: 18944-00-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: N-methyl-valine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-valine hydrochloride(18944-00-8)
• EPA Substance Registry System: N-methyl-valine hydrochloride(18944-00-8)

Safety Data

• Hazardous Substances Data: 18944-00-8(Hazardous Substances Data)

Usage

General Description

N-methyl-valine hydrochloride is a chemical compound of the amino acid valine that has been methylated and combined with hydrochloric acid. It is commonly used in research and pharmaceuticals for its ability to modify the properties of proteins and peptides. This modification can lead to changes in their stability, solubility, and bioactivity, making N-methyl-valine hydrochloride an important tool in the development of new drugs and therapies. N-methyl-valine hydrochloride is also used in the synthesis of complex organic molecules and in the study of protein-protein interactions. Additionally, it has potential applications in the field of bioconjugation and bioorthogonal chemistry.

Upstream product

• 191611-29-7 (S)-3-Methyl-2-methylamino-butyronitrile 
• 45170-31-8 Boc-N-Me-Val-OH 
• 24164-06-5 methyl (2S)-2-[(tert-butoxycarbonyl)(methyl)amino]-3-methylbutanoate 
• 58561-04-9 N-tert-butoxycarbonyl-L-valine methyl ester 
• 6306-52-1 L-valine methylester hydrochloride 
• 91960-27-9 DL-N-(3.5-Dinitro-benzoyl)-N-methyl-valin 
• 191611-24-2 C₁₅H₃₀N₂O₄SSi 
• 191611-28-6 2-Trimethylsilanyl-ethanesulfonic acid ((S)-1-cyano-2-methyl-propyl)-methyl-amide 
• 191611-26-4 2-Trimethylsilanyl-ethanesulfonic acid ((S)-1-cyano-2-methyl-propyl)-amide 
• 10021-64-4 (R)-2-hydroxy-3-methylbutanenitrile 
• 202273-37-8 (S)-3-Chloromethyl-4-isopropyl-2,2-bis-trifluoromethyl-oxazolidin-5-one 
• 6458-35-1 (S)-4-isopropyl-2,2-bis-trifluoromethyl-oxazolidin-5-one 
• 72-18-4 L-valine 
• 946414-57-9 (3S,6S)-N⁽¹⁾,3-dimethyl-3,6-di-iso-propyl-5-methoxy-3,6-dihydropyrazine-2-one 

Relevant articles and documents

Benzoazepine-Fused Isoindolines via Intramolecular (3 + 2)-Cycloadditions of Azomethine Ylides with Dinitroarenes

Aminobenzaldehydes bearing a pendant 3,5-dinitrophenyl group react thermally with N-substituted α-amino acids to form unprecedented benzoazepine-fused isoindolines. The reaction proceeds via a dearomatization/rearomatization sequence involving an intramolecular (3 + 2)-cycloaddition between the in situ formed azomethine ylide and the dinitroarene. Various glycine derivatives are tolerated as well as branched substrates based on cyclic, α-mono-, and α,α-disubstituted amino acids, giving single diastereomers in many cases. The method is scalable and gives products with a nitro group ready for further manipulation.

An efficient synthesis of N-methylamino acids and some of their derivatives

N-Methylamino acid derivatives are obtained in high yield by a stereoselective one-pot procedure from hexafluoroacetone protected amino acids via N-chloromethylation and treatment with triethylsilane/trifluoroacetic acid.