18944-00-8

Usage

Uses

Used in Research and Pharmaceutical Development:
N-methyl-valine hydrochloride is utilized as a modifying agent for proteins and peptides to enhance their stability, solubility, and bioactivity. This modification is crucial in the development of new drugs and therapies, as it can lead to improved efficacy and reduced side effects.
Used in Synthesis of Complex Organic Molecules:
In the field of organic chemistry, N-methyl-valine hydrochloride serves as a building block or intermediate in the synthesis of more complex organic molecules, contributing to the advancement of chemical libraries and the discovery of novel compounds.
Used in Study of Protein-Protein Interactions:
N-methyl-valine hydrochloride is employed as a tool in the study of protein-protein interactions, providing insights into the molecular mechanisms underlying various biological processes and diseases.
Used in Bioconjugation and Bioorthogonal Chemistry:
N-methyl-valine hydrochloride has potential applications in the field of bioconjugation, where it can be used to attach biologically active molecules to other molecules or surfaces. Additionally, it is involved in bioorthogonal chemistry, which allows for the selective modification of biomolecules within complex biological systems without disrupting native chemistry.

Upstream product

• 45170-31-8 Boc-N-Me-Val-OH 
• 24164-06-5 methyl (2S)-2-[(tert-butoxycarbonyl)(methyl)amino]-3-methylbutanoate 
• 58561-04-9 N-tert-butoxycarbonyl-L-valine methyl ester 
• 6306-52-1 L-valine methylester hydrochloride 
• 191611-24-2 C₁₅H₃₀N₂O₄SSi 
• 191611-28-6 2-Trimethylsilanyl-ethanesulfonic acid ((S)-1-cyano-2-methyl-propyl)-methyl-amide 
• 191611-26-4 2-Trimethylsilanyl-ethanesulfonic acid ((S)-1-cyano-2-methyl-propyl)-amide 
• 10021-64-4 (R)-2-hydroxy-3-methylbutanenitrile 
• 202273-37-8 (S)-3-Chloromethyl-4-isopropyl-2,2-bis-trifluoromethyl-oxazolidin-5-one 
• 6458-35-1 (S)-4-isopropyl-2,2-bis-trifluoromethyl-oxazolidin-5-one 
• 72-18-4 L-valine 
• 946414-57-9 (3S,6S)-N⁽¹⁾,3-dimethyl-3,6-di-iso-propyl-5-methoxy-3,6-dihydropyrazine-2-one 
• 946414-56-8 (3R,6S)-N⁽¹⁾,3-dimethyl-3,6-di-iso-propyl-5-methoxy-3,6-dihydropyrazine-2-one 
• 202273-45-8 (S)-4-Isopropyl-3-methyl-2,2-bis-trifluoromethyl-oxazolidin-5-one 

Relevant academic research and scientific papers

Benzoazepine-Fused Isoindolines via Intramolecular (3 + 2)-Cycloadditions of Azomethine Ylides with Dinitroarenes

Aminobenzaldehydes bearing a pendant 3,5-dinitrophenyl group react thermally with N-substituted α-amino acids to form unprecedented benzoazepine-fused isoindolines. The reaction proceeds via a dearomatization/rearomatization sequence involving an intramolecular (3 + 2)-cycloaddition between the in situ formed azomethine ylide and the dinitroarene. Various glycine derivatives are tolerated as well as branched substrates based on cyclic, α-mono-, and α,α-disubstituted amino acids, giving single diastereomers in many cases. The method is scalable and gives products with a nitro group ready for further manipulation.

Diastereoselective synthesis of quaternary α-amino acids from diketopiperazine templates

Sequential enolate alkylations of (S)-N(1)-methyl-5-methoxy-6-isopropyl-3, 6-dihydropyrazin-2-one and (S)-N(1)-p-methoxybenzyl-5-methoxy-6-isopropyl-3,6- dihydropyrazin-2-one proceed with excellent levels of diastereoselectivity (>90% de) affording quaternary α-amino acids in high enantiomeric excess (>98% ee) after deprotection and hydrolysis. This journal is The Royal Society of Chemistry.

An efficient synthesis of N-methylamino acids and some of their derivatives

N-Methylamino acid derivatives are obtained in high yield by a stereoselective one-pot procedure from hexafluoroacetone protected amino acids via N-chloromethylation and treatment with triethylsilane/trifluoroacetic acid.

Asymmetric amino acid synthesis: Mitsunobu reaction on chiral cyanohydrins

BOC(SES)NH was reacted with chiral cyanohydrins using the Mitsunobu reaction to give good yields of protected α-aminonitriles, which were converted to chiral amino and imino acids.