189449-58-9

Upstream product

• 37831-62-2 ethyl 4-chloronicotinate 
• 64485-82-1 (Z)-ethyl 2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetate 
• 189449-54-5 (7R)-7-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(triphenylmethoxyimino)acetamido]-3-chloro-3-cephem-4-carboxylate diphenylmethyl ester 
• 189449-52-3 (Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(triphenylmethoxyimino)acetic acid 
• 128438-00-6 ethyl (2-aminothiazol-4-yl)-2-(Z)-(trityloxyimino)acetate 
• 128438-01-7 (Z)-2-(2-aminothiazol-4-yl)-2-(triphenylmethoxyimino)acetic acid 
• 76-83-5 trityl chloride 
• 626-61-9 4-Chloropyridine 
• 189449-57-8 3-(N-tert-butoxycarbonylaminoethylsulfenylmethyl)-4-chloropyridine 
• 189449-55-6 (7R)-7-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(triphenylmethoxyimino)acetamido]-3-mercapto-3-cephem-4-carboxylate diphenylmethyl ester 

Relevant academic research and scientific papers

Discovery of RWJ-54428 (MC-02,479), a new cephalosporin active against resistant gram-positive bacteria

The discovery of RWJ-54428 (MC-02,479), a new cephalosporin displaying promising activity against sensitive and resistant Gram-positive bacteria, is described. Progressive structural modification from the previously reported 3-phenylthiocephem MC-02,331 afforded an overall increase in potency against MRSA while retaining other key properties such as acceptable solubility and serum binding. Evaluation of the in vitro potency and in vivo efficacy of a series of closely related compounds resulted in selection of RWJ-54428 (MC-02,479) for further studies.