189452-07-1

Basic information

• Product Name: 4-Methoxy-N-(4-methyl-piperazin-1-carbothioyl)benzamide
• Synonyms: 4-Methoxy-N-(4-methyl-piperazin-1-carbothioyl)benzamide;4-methoxy-N-[(4-methyl-1-piperazinyl)carbonothioyl]benzamide
• CAS NO: 189452-07-1
• Molecular Formula: C14H19 N3 O2 S
• Molecular Weight: 293.38
• Mol File: 189452-07-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.222±0.06 g/cm3(Predicted)
• PKA: 10.79±0.70(Predicted)
• CAS DataBase Reference: 4-Methoxy-N-(4-methyl-piperazin-1-carbothioyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxy-N-(4-methyl-piperazin-1-carbothioyl)benzamide(189452-07-1)
• EPA Substance Registry System: 4-Methoxy-N-(4-methyl-piperazin-1-carbothioyl)benzamide(189452-07-1)

Safety Data

• Hazardous Substances Data: 189452-07-1(Hazardous Substances Data)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 333-20-0 potassium thioacyanate 
• 100-07-2 4-methoxy-benzoyl chloride 

Downstream Products

• 189452-58-2 4-methoxy-N-[(methoxycarbonyl)methyl]-N'-[(1-methylpiperazin-1-yl)(thiocarbonyl)]benzamidine 

Relevant articles and documents

Versatile novel syntheses of imidazoles

A novel ring transformation/desulfurization of substituted 2-methyl-1,2,4-thiadiazolium salts 2 provides a versatile entry to imidazoles 3 with a variety of substituents. Simple one-pot procedures combine the preparation of starting 1,2,4-thiadiazolium salts 2 from N-(thiocarbonyl)-N'-methylamidines 1 or 1,2,4-dithiazolium triiodides 6 with the ring transformation/desulfurization to the imidazoles 3. Alternatively, N-(thiocarbonyl)-N'-methylamidines 1 can be transformed to imidazoles 3 or to 1-substituted imidazoles 5 via S-methylation and elimination of methylthiol. In the same manner, a new entry to 4H-imidazoles 8 could be developed.