18952-41-5

Basic information

• Product Name: Methanethioamide, N-methyl-
• CAS NO: 18952-41-5
• Molecular Formula: C2H5NS
• Molecular Weight: 75.1344
• Mol File: 18952-41-5.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Methanethioamide, N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanethioamide, N-methyl-(18952-41-5)
• EPA Substance Registry System: Methanethioamide, N-methyl-(18952-41-5)

Safety Data

• Hazardous Substances Data: 18952-41-5(Hazardous Substances Data)

Usage

General Description

Methanethioamide, N-methyl- is a chemical compound with the formula C2H5NS. It is a sulfur-containing compound with a methyl group attached to the nitrogen atom. Methanethioamide, N-methyl- is used primarily as an intermediate in the synthesis of other organic compounds. It is also used in the production of pharmaceuticals and agrochemicals. Methanethioamide, N-methyl- is a white to off-white solid with a pungent odor and is soluble in water and other organic solvents. It is important to handle this compound with care due to its potential health hazards and it should be used in a well-ventilated area.

Upstream product

• 556-61-6 methyl thioisocyanate 
• 42445-46-5 2-bromo-1-(4-methylsulfanyl-phenyl)-ethanone 
• 197905-69-4 2-[2-(4-methylsulfanylphenyl)-2-oxoethyl]-3-oxobutanic acid methyl ester 
• 78-94-4 methyl vinyl ketone 
• 3446-89-7 4-(Methylthio)benzaldehyde 
• 123-39-7 N-Methylformamide 
• 74-90-8 hydrogen cyanide 
• 74-89-5 methylamine 

Downstream Products

• 6610-29-3 4-methylthiosemicarbazide 
• 77827-61-3 Zn⁽²⁺⁾*2Cl^(1-)*2HCSNHCH₃=ZnCl₂(HCSNHCH₃)2 
• 123-39-7 N-Methylformamide 
• 99380-74-2 ((1S,2S,6R,7R)-8-Methyl-3,5,9-trioxo-4-oxa-10-thia-8-aza-tricyclo[5.2.1.0^2,6]dec-1-yl)-acetic acid 

Relevant articles and documents

A fluorescent target-guided Paal-Knorr reaction

It has become increasingly apparent that high-diversity chemical reactions play a significant role in the discovery of bioactive small molecules. Here, we describe an expanse of this paradigm, combining a ‘target-guided synthesis’ concept with Paal-Knorr chemistry applied to the preparation of fluorescent ligands for human prostaglandin-endoperoxide synthase (COX-2).

AN IMPROVED PROCESS FOR THE PREPARATION OF PYRROLE DERIVATIVES

The present invention relates to an improved process for the preparation of pyrroles derivatives having hypolipidemic and hypocholesteremic activities. In particular, the invention relates to an improved process for the preparation of 2- ethoxy-3-(4-(2-(2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-1-yl)ethoxy) phenyl)propanoate and its pharmaceutically acceptable salts, hydrates, solvates, polymorphs or intermediates thereof. The invention also relates to an improved process for the preparation of mesylate compound (A1).

A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity

We report the synthesis and bio-pharmacological evaluation of a class of pyrrole derivatives featuring a small appendage fragment (carbaldehyde, oxime, nitrile) on the central core. Compound 1c proved to be extremely effective in vivo, showing an interesting anti-nociceptic profile that is comparable to reference compounds already marketed, hence representing a great stimulus for a further improvement of this class of molecules.