18960-29-7

Usage

Uses

Used in Pharmaceutical Research:
1-(4-Trifluoromethyl)phenylbiguanide hydrochloride is used as a research compound for exploring its potential biological activity and therapeutic effects. Its unique structure with a trifluoromethylphenyl group may offer novel pharmacological properties, making it a valuable candidate for further study in the development of new drugs.
Used in Medical Research:
In the medical research field, 1-(4-Trifluoromethyl)phenylbiguanide hydrochloride is utilized to investigate its potential applications in treating various diseases and conditions. Its biguanide origin and trifluoromethylphenyl modification may provide insights into new treatment options and therapeutic strategies.

InChI:InChI=1/C9H10F3N5.ClH/c10-9(11,12)5-1-3-6(4-2-5)16-8(15)17-7(13)14;/h1-4H,(H6,13,14,15,16,17);1H

Upstream product

• 455-14-1 4-trifluoromethylphenylamine 
• 127099-85-8 N-Cyanoguanidine 

Downstream Products

• 86176-98-9 N-(4-Hydroxy-6-trifluoromethyl-pyrimidin-2-yl)-N'-(4-trifluoromethyl-phenyl)-guanidine 
• 3796-35-8 1-carbamimidamido-N-[4-(trifluoromethyl)phenyl]methanimidamide 
• 86177-30-2 N-[4-(4-Benzyloxy-3-diethylaminomethyl-phenylamino)-6-trifluoromethyl-pyrimidin-2-yl]-N'-(4-trifluoromethyl-phenyl)-guanidine 
• 86177-27-7 N-{4-[4-Hydroxy-3-(4-methyl-piperazin-1-ylmethyl)-phenylamino]-6-trifluoromethyl-pyrimidin-2-yl}-N'-(4-trifluoromethyl-phenyl)-guanidine 
• 86177-29-9 N-[4-(3-Diethylaminomethyl-4-methoxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-yl]-N'-(4-trifluoromethyl-phenyl)-guanidine 
• 86177-26-6 N-[4-(3-Diethylaminomethyl-4-hydroxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-yl]-N'-(4-trifluoromethyl-phenyl)-guanidine 
• 86177-28-8 N-[4-(3-Ethylaminomethyl-4-methoxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-yl]-N'-(4-trifluoromethyl-phenyl)-guanidine 
• 86177-25-5 N-[4-(3-Dimethylaminomethyl-4-hydroxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-yl]-N'-(4-trifluoromethyl-phenyl)-guanidine 

Relevant academic research and scientific papers

Identifying Lysophosphatidic Acid Acyltransferase β (LPAAT-β) as the Target of a Nanomolar Angiogenesis Inhibitor from a Phenotypic Screen Using the Polypharmacology Browser PPB2

By screening a focused library of kinase inhibitor analogues in a phenotypic co-culture assay for angiogenesis inhibition, we identified an aminotriazine that acts as a cytostatic nanomolar inhibitor. However, this aminotriazine was found to be completely inactive in a whole-kinome profiling assay. To decipher its mechanism of action, we used the online target prediction tool PPB2 (http://ppb2.gdb.tools), which suggested lysophosphatidic acid acyltransferase β (LPAAT-β) as a possible target for this aminotriazine as well as several analogues identified by structure–activity relationship profiling. LPAAT-β inhibition (IC50 ≈15 nm) was confirmed in a biochemical assay and by its effects on cell proliferation in comparison with a known LPAAT-β inhibitor. These experiments illustrate the value of target-prediction tools to guide target identification for phenotypic screening hits and significantly expand the rather limited pharmacology of LPAAT-β inhibitors.

BIGUANIDE COMPOUND AND USE THEREOF

The present invention relates to a guanidine compound and a use thereof, and more specifically, to a guanidine derivative showing excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence; a preparation method thereof; and a pharmaceutical composition containing the same as an active ingredient. Compared to existing drugs, the guanidine derivative according to the present invention shows excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence even with small doses, and may thus be effectively used in preventing or treating various cancers such as uterine cancer, breast cancer, stomach cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, liver cancer, etc., inhibiting cancer cell proliferation and cancer metastasis.

Synthesis and antifilarial activity of N-[4-[[4-alkoxy-3-[(dialkylamino)methyl]phenyl]amino]-2-pyrimidinyl]-N'-ph enylguanidines

A series of N-[4-[[4-alkoxy-3-[(dialkylamino)methyl]phenyl]amino]-2-pyrimidinyl]-N' -phenylguanidines have been synthesized for antifilarial evaluation. Reaction of the appropriate benzenamines with N-cyanoguanidine, followed by condensation of the result