189625-51-2Relevant articles and documents
Synthesis method of somaglutide fatty acid side chain derivative
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Paragraph 0056-0063, (2021/04/21)
The invention relates to a synthesis method of a somaglutide fatty acid side chain I. The method comprises the following steps: with octadecyl diacid as an initial raw material, carrying out esterification hydrolysis on octadecyl diacid and benzyl alcohol to obtain an intermediate I; subjecting the intermediate I to reacting with TSTU to obtain an active ester of the intermediate I, namely an intermediate II; subjecting the intermediate II to reacting with 1-benzyl-L-glutamic acid to obtain an intermediate III; subjecting the intermediate III to reacting with TSTU to obtain an active ester of the intermediate III, namely an intermediate IV; subjecting the intermediate IV to reacting with AEEA-AEEA to obtain an intermediate V; subjecting the intermediate V to reacting with TSTU to obtain an intermediate VI; and removing a benzyl group from the intermediate VI under the action of Pd/C and hydrogen to obtain the somaglutide fatty acid side chain I. The method for preparing the semaglutide fatty acid side chain I has the advantages of few reaction types, mild reaction conditions in each step, controllable quality of intermediates in each step, high overall yield, economic performance and effectiveness, and suitableness for large-scale production.
Method for preparing alkyl diacid monobenzyl ester
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Paragraph 0031-0032, (2019/12/25)
The invention relates to a method for preparing an alkyl diacid monobenzyl ester, and belongs to the technical field of chemical engineering. According to the method provided by the invention, an alkyl diacid is used as a raw material and is subjected to esterification reaction with benzyl bromide or benzyl chloride in a mixed system of an organic solvent and water under the action of an alkali toobtain the alkyl diacid monobenzyl ester. The method is good in selectivity, convenient to operate, high in yield, low in cost and beneficial to implementation.