189746-19-8

Upstream product

• 6340-55-2 2-chloro-4-methyl-6-methoxyquinoline 
• 189746-20-1 2,6-dimethoxy-4-methyl-quinoline 

Downstream Products

• 189746-21-2 5-chloro-2,6-dimethoxy-4-methyl-8-nitro-quinoline 
• 1260253-45-9 8-[(1-methyl-4-phthalimido)-butyl]-amino-2,6-dimethoxy-4-methyl-5-phenyl-quinoline 
• 1260253-44-8 C₁₈H₁₈N₂O₂ 
• 1260253-66-4 2,6-dimethoxy-4-methyl-8-nitro-5-(3-trifluoromethylphenyl)-quinoline 
• 1260253-43-7 C₁₈H₁₆N₂O₄ 
• 1260253-40-4 8-[(4-amino-1-methyl)-butyl]-amino-2,6-dimethoxy-4-methyl-5-phenyl-quinoline 
• 1260253-55-1 8-[(4-amino-1-methyl)-butyl]-amino-5-(3,4-dichlorophenyl)-2,6-dimethoxy-4-methyl-quinoline succinate 
• 1260253-53-9 8-[(4-amino-1-methyl)-butyl]-amino-2,6-dimethoxy-4-methyl-5-(3-methylphenyl)-quinoline succinate 
• 1260253-51-7 8-[(4-amino-1-methyl)-butyl]-amino-2,6-dimethoxy-5-(3-methoxyphenyl)-4-methylquinoline succinate 
• 1260253-49-3 8-[(4-amino-1-methyl)-butyl]-amino-2,6-dimethoxy-4-methyl-5-(4-trifluoromethylphenyl)-quinoline succinate 
• 1260253-47-1 8-[(4-amino-1-methyl)-butyl]-amino-2,6-dimethoxy-4-methyl-5-(3-trifluoromethylphenyl)-quinoline succinate 
• 1260253-41-5 8-[(4-amino-1-methyl)-butyl]-amino-2,6-dimethoxy-4-methyl-5-phenyl-quinoline succinate 
• 1260253-90-4 8-[(1-methyl-4-phthalimido)-butyl]-amino-2,6-dimethoxy-4-methyl-5-(3,4-dichlorophenyl)-quinoline 
• 1260253-89-1 8-[(1-methyl-4-phthalimido)-butyl]-amino-2,6-dimethoxy-4-methyl-5-(3-methylphenyl)-quinoline 

Relevant academic research and scientific papers

Antimalarial activity of novel 5-aryl-8-aminoquinoline derivatives

In an attempt to separate the antimalarial activity of tafenoquine (3) from its hemolytic side effects in glucose-6-phosphate dehydrogenase (G6PD) deficiency patients, a series of 5-aryl-8-aminoquinoline derivatives was prepared and assessed for antimalar

Process for the preparation of anti-malarial drugs

The invention relates to novel intermediates and processes for the preparation of quinoline compounds useful as anti-malarial drugs and novel intermediates useful in the process. A process for the preparation of a compound of formula (I) in which R1is C1-6alkyl; R2and R3are independently hydrogen, halogen, trifluoromethyl or C1-6alkoxy; R4is C1-6alkyl; R5is hydrogen or C1-6alkyl; and R6or amino which comprises reacting a compound of formula (II) in which R1, R4and R5are as defined in formula (I) and X is a leading group with a compound of formula (III).