18979-55-0

Basic information

• Product Name: 4-Hexyloxyphenol
• Synonyms: P-HEXYLOXYPHENOL;HYDROQUINONE MONOHEXYL ETHER;HYDROQUINONE MONO-N-HEXYL ETHER;4-N-HEXYLOXYPHENOL;4-HEXYLOXYPHENOL;4-(HEXYLOXY)BENZENOL;4-(hexyloxy)-pheno;Phenol, 4-(hexyloxy)-
• CAS NO: 18979-55-0
• Molecular Formula: C₁₂H₁₈O₂
• Molecular Weight: 194.27
• EINECS: 242-713-1
• Product Categories: Building Blocks for Liquid Crystals;Functional Materials;Phenols (Building Blocks for Liquid Crystals);Organic Building Blocks;Oxygen Compounds;Phenols;Building Blocks;C9 to C20+;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds
• Mol File: 18979-55-0.mol
• Article Data: 23

Chemical Properties

• Melting Point: 45-47 °C(lit.)
• Boiling Point: 112 °C / 3mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.0010 (rough estimate)
• Vapor Pressure: 0.000345mmHg at 25°C
• Refractive Index: 1.5050 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: within almost transparency in Methanol
• PKA: 10.36±0.15(Predicted)
• BRN: 473079
• CAS DataBase Reference: 4-Hexyloxyphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hexyloxyphenol(18979-55-0)
• EPA Substance Registry System: 4-Hexyloxyphenol(18979-55-0)

Safety Data

• Hazard Codes: Xn,N,Xi
• Statements: 22-36/37/38-51/53
• Safety Statements: 26-36-61-37/39
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 18979-55-0(Hazardous Substances Data)

Usage

Chemical Properties

light beige to brown crystalline solid

Uses

Intermediates of Liquid Crystals

General Description

4-(Hexyloxy)phenol is a lead anti-melanoma agent against B16-F0 melanoma cells with minimal metabolism by rat liver P450 microsomal preparation.

InChI:InChI=1/C12H18O2/c1-2-3-4-5-10-14-12-8-6-11(13)7-9-12/h6-9,13H,2-5,10H2,1H3

Upstream product

• 123-31-9 hydroquinone 
• 111-27-3 hexan-1-ol 
• 5736-94-7 4-(hexyloxy)benzaldehyde 
• 123-08-0 4-hydroxy-benzaldehyde 
• 142627-91-6 4-(6-hydroxyhexyloxy)phenol 
• 4286-55-9 1-bromo-6-hexanol 
• 103-16-2 4-Benzyloxyphenol 
• 67399-85-3 1-(benzyloxy)-4-(hexyloxy)benzene 
• 111-25-1 1-bromo-hexane 
• 637-88-7 1,4-Cyclohexanedione 
• 1142-39-8 para-hexyloxybenzoic acid 
• 110-54-3 hexane 
• 106-51-4 p-benzoquinone 
• 554-13-2 lithium carbonate 

Downstream Products

• 61733-33-3 4-(4-n-pentylphenyl)-benzoic acid 4'-n-hexyloxyphenyl ester 
• 102841-34-9 Benzene-1,2,4-tricarboxylic acid tris-(4-hexyloxy-phenyl) ester 
• 148731-15-1 4-hexyloxyphenyl 4-(benzyloxy) benzoate 
• 102101-70-2 C₄₃H₅₂O₈ 
• 38454-34-1 4-Hexanoyloxy-benzoic acid 4-hexyloxy-phenyl ester 
• 126164-89-4 (1R,2S,4R)-4-Butyl-2-methyl-cyclohexanecarboxylic acid 4-hexyloxy-phenyl ester 
• 126164-95-2 (1R,2S,4R)-4-Hexyl-2-methyl-cyclohexanecarboxylic acid 4-hexyloxy-phenyl ester 
• 126198-31-0 4-hexyloxyphenyl trans-4-propyl-cis-2-methylcyclohexane-1-r-carboxylate 
• 105343-74-6 5-Pentyloxy-pyrimidine-2-carboxylic acid 4-hexyloxy-phenyl ester 
• 133883-34-8 4-(5-Hexyl-pyrimidin-2-yl)-benzoic acid 4-hexyloxy-phenyl ester 
• 102101-56-4 C₄₄H₅₄O₈ 
• 82356-01-2 4-(4-Propyl-bicyclo[2.2.2]oct-1-yl)-benzoic acid 4-hexyloxy-phenyl ester 
• 82356-07-8 4-(4-Pentyl-bicyclo[2.2.2]oct-1-yl)-benzoic acid 4-hexyloxy-phenyl ester 
• 82356-11-4 4-(4-Hexyl-bicyclo[2.2.2]oct-1-yl)-benzoic acid 4-hexyloxy-phenyl ester 

Related news

Laccase-mediated functionalization of chitosan with 4-Hexyloxyphenol (cas 18979-55-0) enhances antioxidant and hydrophobic properties of copolymer07/18/2019

An effective method to functionalize chitosan with 4-hexyloxyphenol (HP) under homogeneous reaction conditions was developed using laccase as the catalyst. The resulting copolymer was characterized for chemical structure, grafted-HP content, surface morphology, thermal stability, antioxidant cap...detailed

Relevant articles and documents

Allylphenols as a new class of human 15-lipoxygenase-1 inhibitors

In this study, a series of mono- and diallylphenol derivative were designed, synthesized, and evaluated as potential human 15-lipoxygenase-1 (15-hLOX-1) inhibitors. Radical scavenging potency of the synthetic allylphenol derivatives was assessed and the results were in accordance with lipoxygenase (LOX) inhibition potency. It was found that the electronic natures of allyl moiety and para substituents play the main role in radical scavenging activity and subsequently LOX inhibition potency of the synthetic inhibitors. Among the synthetic compounds, 2,6-diallyl-4-(hexyloxy)phenol (42) and 2,6-diallyl-4-aminophenol (47) showed the best results for LOX inhibition (IC50 = 0.88 and 0.80 μM, respectively).

Chemoselective deoxygenation of ether-substituted alcohols and carbonyl compounds by B(C6F5)3-catalyzed reduction with (HMe2SiCH2)2

B(C6F5)3-catalyzed deoxygenation of ether-substituted alcohols and carbonyl compounds has been developed using (HMe2SiCH2)2 as the reductant. This unique reagent shows distinct superiority over traditional one silicon-centered hydrosilanes, giving the corresponding alkanes in high yields with good tolerance of ethers, aryl halides and alkenes. The control experiments suggest that (HMe2SiCH2)2 might facilitate the approach in an intramolecular Si/O activation manner.

B(C6F5)3-Catalyzed Chemoselective Defunctionalization of Ether-Containing Primary Alkyl Tosylates with Hydrosilanes

Catalytic C(sp3)?O bond cleavage promoted by B(C6F5)3 /Et3SiH proceeds preferentially with primary tosylates in the presence of primary and secondary silyl ethers and aryl ethers. This reactivity difference enables the chemoselective defunctionalization of several 1,n-diols, and the efficiency of the new procedure is highlighted by the selective deoxygenation of the hydroxymethyl group of an orthogonally protected carbohydrate. Tosylates with an adjacent phenyl group are cleaved with anchimeric assistance.