189809-44-7Relevant academic research and scientific papers
α-Nitrogenated organolithium compounds from N-(tosylmethyl)amides
Alonso, Diego A.,Alonso, Emma,Nájera, Carmen,Yus, Miguel
, p. 491 - 492 (1997)
Deprotonation of α-amido sulfones 7 with BunLi at -90°C followed by reaction with electrophiles leads, depending on the substitution on the amidic nitrogen to enamides 10 (secondary amides 7a,b) or functionalised α-amido sulfones 12 (tertiary amides 7c,d). Naphthalene-catalysed lithiation of tertiary α-amido sulfones 7c,d in the presence of electrophiles (Barbier conditions) at -78°C affords functionalised amides 13.
α-Nitrogenated organolithium compounds from α-amidomethyl and α-aminomethyl sulfones
Alonso, Diego A.,Alonso, Emma,Najera, Carmen,Ramon, Diego J.,Yus, Miguel
, p. 4835 - 4856 (2007/10/03)
Successive reaction of α-amidomethyl sulfones 7a,b, derived from primary amides, with n-butyllithium and primary alkyl bromides (CH2 = CHCH2Br, CH2 = CMeCH2Br, CH2 = CBrCH2Br, CH ≡ CCH
