189937-22-2

Usage

Uses

Used in Pharmaceutical Industry:
2,6-Dibromo-4-methylacetanilide is used as an intermediate in the synthesis of various pharmaceuticals for its ability to be chemically modified and incorporated into drug molecules, contributing to the development of new medications.
Used in Dye Industry:
In the dye industry, 2,6-Dibromo-4-methylacetanilide is used as a reagent in the production of dyes due to its chemical properties that can be utilized to create a range of colorants for various applications.
Used in Organic Synthesis:
2,6-Dibromo-4-methylacetanilide is used as a reagent in organic synthesis for its potential to participate in a variety of chemical reactions, facilitating the creation of complex organic molecules for research and commercial purposes.
Used in Medicinal Chemistry:
In medicinal chemistry, 2,6-Dibromo-4-methylacetanilide is used for its potential applications in the development of new drugs, given its structural features that can be optimized for specific therapeutic targets.
Used in Materials Science:
2,6-Dibromo-4-methylacetanilide is utilized in materials science for its potential to contribute to the development of new materials with unique properties, such as those with enhanced stability or specific interactions with other molecules.

Upstream product

• 6968-24-7 2,6-Dibromo-4-methylaniline 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 
• 103-89-9 4-Methylacetanilide 

Downstream Products

• 1426169-48-3 {bis[N,N'-(4-methyl-2,6-diphenylphenyl)imino]acenaphthene}dibromonickel 
• 1426169-45-0 bis[N,N'-(4-methyl-2,6-diphenylphenyl)imino]acenaphthene 
• 6968-24-7 2,6-Dibromo-4-methylaniline 
• 2941-71-1 2,6-dimethylbenzothiazole 
• 113571-01-0 2,6-Dibromo-4-methylthioacetanilide 

Relevant academic research and scientific papers

Highly active ortho-phenyl substituted α-diimine Nickel(II) catalysts for "chain walking polymerization" of ethylene: Synthesis of the nanosized dendritic polyethylene

Three new α-diimine Ni(II) complexes {bis[N,N′-(4-fluoro-2,6- diphenylphenyl)imino]acenaphthene}dibromonickel 4a, {bis[N,N′-(4-chloro-2, 6-diphenylphenyl)imino]acenaphthene}dibromonickel 4b, and {bis[N,N′-(4- methyl-2,6-diphenylphenyl)imino]acenaphthene}dibromonickel 4c, were synthesized and characterized. The crystal structure of the complex 4a was determined by X-ray crystallography. Complex 4a has pseudo-tetrahedral geometry about the nickel center, showing C2v molecular symmetry. These complexes, activated by diethylaluminum chloride (DEAC) were tested in the polymerization of ethylene under mild conditions. Complex 4a bearing 2,6-diphenyl and strong electron-withdrawing 4-fluorine groups, activated by diethylaluminum chloride (DEAC) shows highly catalytic activity for the polymerization of ethylene [4.95 × 106 g PE/(mol Ni h bar)] and produced dendritic polyethylene (153.3 branches/1000 C). The dendritic polyethylene particle size obtained by 4a/DEAC can be controlled in the 1-20 nm under 0.2 bar ethylene pressure, and could be expected to become a nano-targeted drug carrier after modified with water-soluble oligo(ethylene glycol) (OEG).

SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS

The invention relates to substituted benzothiazoles, benzoxazoles—and their counterparts having pyridine and pyrimidine rings replacing the benzene ring—that are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula I: in which A and B are carbocycles or heterocycles. A particular embodiment is

Facile synthesis of 2′-acetamido-m-terphenyls via Suzuki coupling

Reaction of 2′-amido-m-terphenyl with NaOH and Br2 gave substituted phenanthridinone instead of undergoing rearrangement to give acetamido-m-terphenyl. Thermolysis of 2′-azido-m-terphenyl also gave the phenanthridinone in good yield. The synthesis of 2′-m-terphenyls was accomplished via Suzuki coupling.