189949-98-2

Upstream product

• 50373-10-9 methyl ecgonidine 
• 352-13-6 4-flourophenylmagnesium bromide 
• 168143-65-5 methyl (1R,5S)-8-methyl-3-(((trifluoromethyl)sulfonyl)oxy)-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate 
• 168143-68-8 O-1104 
• 85506-18-9 (1R)-(-)-2-carbomethoxy-3-tropinone 
• 50370-59-7 2β-carbomethoxy-3β-(4-fluorophenyl)tropane 
• 53898-64-9 2β-carboxy-3β-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane 

Downstream Products

• 189950-04-7 (1R,2S,3S,5S)-3-(4-Fluoro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid [2-(4-methoxy-benzylsulfanyl)-ethyl]-amide 
• 306740-53-4 2β-carboxylic acid methoxymethylamide-3β-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane 
• 189950-08-1 2-{[(1R,2R,3S,5S)-3-(4-Fluoro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-ylmethyl]-[2-(4-methoxy-benzylsulfanyl)-ethyl]-amino}-N-[2-(4-methoxy-benzylsulfanyl)-ethyl]-acetamide 
• 189950-10-5 N-[(1R,2R,3S,5S)-3-(4-Fluoro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-ylmethyl]-N,N'-bis-[2-(4-methoxy-benzylsulfanyl)-ethyl]-ethane-1,2-diamine 
• 189950-06-9 [(1R,2R,3S,5S)-3-(4-Fluoro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-ylmethyl]-[2-(4-methoxy-benzylsulfanyl)-ethyl]-amine 
• 306740-58-9 N-[2-(3'-N'-propyl-(1''R)-3''β-(4-fluorophenyl)tropane-2''β-(1-propanoyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol 
• 306740-56-7 2β-(1-propanoyl)-3β-(4-fluorophenyl)-8-azabicyclo[3.2.1]octane 
• 162809-70-3 2β-(1-propanoyl)-3β-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane 

Relevant academic research and scientific papers

A second-generation 99mtechnetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brain

The dopamine transporter (DAT), located presynaptically on dopamine neurons, provides a marker for Parkinson's disease (Pd) and attention deficit hyperactivity disorder (ADHD). In ADHD, DAT density levels are elevated, while in Pd these levels are deplete

Intermediates for the synthesis of radiolabelled tropanes

The compounds of the present invention comprise a tropane compound or ligand that selectively binds to tropane recognition sites, e.g., neuron transporters such as that DAT. The tropane ligand is radiolabeled with a radioactive technetium or rhenium by a chelating ligand which is attached to the tropane ligand by a linker. Tropane compounds or ligands useful in the pratice of the present invention can generally be represented by formula II where R1 and R2 are defined as above and where R1 can also be substituted at the C4 position of the tropane ring: Any tropane compound of the general formula II is useful in the present invention so long as it binds to DAT. Useful tropane analogs have a 3α-group,i.e., are of the boat configuration. Intermediates for the synthesis of the radiolabeled tropanes are claimed.

Synthesis and binding affinities of 2β-(3-iodoallyloxycarbonyl)-3β-(4-substituted-aryl)tropane analogues as ligands for the dopamine transporter studies

Tropane analogues from cocaine, which is known to be one of the most reinforcing and addictive compounds, were designed, synthesized, and characterized for inhibition of presynaptic uptake of dopamine (DA) in brain. Eight new derivatives of 3β-aryl-2β-(3-iodoallyloxycarbonyl)tropanes were synthesized and tested for their potential abilities to displace [3H]2β-carbomethoxy-3β-(4-fluorophenyl)tropane (WIN 35,428) binding to the rat striatal membranes.

Synthesis and characterization of technetium-99m-labeled tropanes as dopamine transporter-imaging agents

In the development of novel Tc-99m-labeled tropane derivatives as dopamine transporter (reuptake site)-imaging agents, a series of neutral and lipophilic complexes containing bis-(aminoethanethiol) as a neutral complexing moiety for a [99mTc]Tc