18995-35-2

Usage

Uses

1. Used in Silico Prediction of Drug-Induced Myelotoxicity:
1-tert-Butoxy-4-chlorobenzene is utilized as a reagent in the Naive Bayes method, a statistical technique employed in computational biology for predicting drug-induced myelotoxicity. This application aids in the early stages of drug development, helping to identify potential side effects and streamline the process of drug discovery.
2. Reagent for the Preparation of p-tert-butoxystyrene:
As a reagent, 1-tert-Butoxy-4-chlorobenzene is used in the synthesis of p-tert-butoxystyrene, an important intermediate in the production of various drugs, agrochemicals, and monomers. The compound's unique structure allows for selective reactions, facilitating the creation of a wide range of products.
3. Used in the Agrochemical Industry:
1-tert-Butoxy-4-chlorobenzene is employed as a key intermediate in the agrochemical industry for the development of new pesticides and other chemical products. Its use in this sector contributes to the advancement of more effective and environmentally friendly solutions for crop protection and management.
4. Used in the Monomers Industry:
In the monomers industry, 1-tert-Butoxy-4-chlorobenzene serves as a valuable intermediate for the synthesis of various polymers and resins. Its unique properties enable the production of materials with specific characteristics, such as enhanced durability, heat resistance, or chemical stability, which are essential for various applications in the plastics, coatings, and adhesives markets.

InChI:InChI=1/C10H13ClO/c1-10(2,3)12-9-6-4-8(11)5-7-9/h4-7H,1-3H3

Upstream product

• 507-20-0 tertiary butyl chloride 
• 106-48-9 4-chloro-phenol 
• 6669-13-2 t-butyl phenyl ether 
• 106-39-8 bromochlorobenzene 
• 865-47-4 potassium tert-butylate 
• 927-83-3 di-t-butyldiazene 
• 115-11-7 isobutene 

Downstream Products

• 1070716-48-1 2-(4-tert-butoxyphenyl)-3-methylbutanal 
• 1158985-06-8 N-phenylsulfonyl-2-(4-tert-butoxyphenyl)indole 
• 1158984-98-5 2-(4-tert-butoxyphenyl)furan 
• 808142-44-1 2-(4-tert-butoxyphenyl)thiophene 
• 95418-58-9 4-tert-butoxystyrene 
• 1158985-08-0 1-tert-butoxy-4-cyclopropylbenzene 
• 1158985-01-3 5'-(4-tert-butoxyphenyl)-4-methyl-2,2'-bithiophene 
• 1158985-03-5 N-(tert-butoxycarbonyl)-2-(4-tert-butoxyphenyl)pyrrole 
• 1158985-00-2 2-(4-(tert-butoxy)phenyl)benzofuran 
• 57120-36-2 4-(tert-butoxy)aniline 
• 938063-51-5 2-(4-(tert-butoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 28145-35-9 4-(2-chloroethyl)phenol 
• 56718-71-9 4-(2-methoxyethyl)phenol 

Relevant academic research and scientific papers

Preparation method of p-(2-methoxyl)ethyl phenol

The invention discloses a preparation method of p-(2-methoxyl) ethyl phenol. According to the preparation method, p-chlorophenol is taken as the raw material, after etherification reactions, p-chlorophenol with a protected phenolic hydroxyl group is obtained, and after Grignard reactions, chlorination reactions, and methoxyl substitution reactions, p-(2-methoxyl)ethyl phenol is generated. The provided preparation method has the advantages of easily available raw materials, mild reaction conditions, high safety coefficient, strong operability, simple technology, easy industrialization, high product purity, and stable quality. The prepared p-(2-methoxyl)ethyl phenol totally meets the using requirements of medical intermediates.

Copper Catalyzed sp3 C-H Etherification with Acyl Protected Phenols

A variety of acyl protected phenols AcOAr participate in sp3 C-H etherification of substrates R-H to give alkyl aryl ethers R-OAr employing tBuOOtBu as oxidant with copper(I) β-diketiminato catalysts [CuI]. Although 1°, 2°, and 3° C-H bonds may be functionalized, selectivity studies reveal a preference for the construction of hindered, 3° C-OAr bonds. Mechanistic studies indicate that β-diketiminato copper(II) phenolates [CuII]-OAr play a key role in this C-O bond forming reaction, formed via transesterification of AcOAr with [CuII]-OtBu intermediates generated upon reaction of [CuI] with tBuOOtBu.

Development of a Triazine-Based tert-Butylating Reagent, TriAT-tBu

A new tert-butylating reagent, 2,4,6-tris(tert-butoxy)-1,3,5-triazine (TriAT-tBu) has been developed for the acid-catalyzed tert-butylation of alcohols and carboxylic acids. The reaction of various alcohols and carboxylic acids with TriAT-tBu in the presence of a catalytic amount of an acid provided the corresponding tert-butyl ethers and esters in good to high yields. TriAT-tBu is an air-stable solid synthesized in good yield from inexpensive starting materials, namely, cyanuric chloride, tBuOH, and sodium hydride.

Gold(I)-catalyzed direct C-H arylation of pyrazine and pyridine with aryl bromides

An efficient procedure for the direct C-H arylation of electron-poor aromatics such as pyrazine and pyridine with aryl bomides is described. In the presence of catalytic amount of Cy3PAuCl and with the use of t-BuOK as base, pyrazine undergoes the direct C-H arylation with aryl bromides at 100 °C, and the yields of the arylated products depend on the nature of aryl bromides. In the cases of electron-rich aryl bromides used, the arylated pyrazines can be obtained in good to high yields. For electron-poor aryl bromides, the addition of AgBF4 is the crucial point to accelerate the coupling reaction to give the arylated products in moderate yields. Pyridine also reacts with electron-rich aryl bromides catalyzed by Cy3PAuCl to give a mixture of arylated regioisomers in moderate yield. However, in order to realize the direct C-H arylation of pyridine with electron-poor aryl bromides, the addition of silver salt as additive and a milder reaction temperature (60 °C) are required.

Protection of phenols as t-butyl ethers under mild conditions

Zinc mediated selective O-y-butylation of phenols has been carried out in good to excellent yields under mild conditions. No trace of C-t-butylation was observed.

Kaolin-assisted Aromatic Chlorination and Bromination

Moist kaolin catalyses the regioselective and high-yielding chlorination and bromination of C6H5OR (R = C1-C8 alkyl. Bu1, allyl, cyclohexyl, benzyl) to 4-XC6H4OR (X = Cl and Br, respectively) with NaCl02 and Mn(acac)3 in CH2Cl2 in the absence and presence of NaBr, respectively, under mild and neutral conditions.

Selective aromatic chlorination of activated arenes with sodium chlorite, (salen)manganese(III) complex, and alumina in dichloromethane

The reaction of alkyl phenyl ethers with sodium chlorite in dichloromethane in the presence of a (salen)manganese(III) complex and alumina preloaded with a small amount of water afforded monochlorination products with unusually high para selectivities under mild conditions. The NaClO2-based biphasic system can also be successfully used for the regioselective monochlorination of substituted anisoles and polymethoxybenzenes.

Regiospecific aromatic chlorination of alkyl phenyl ethers using sodium chlorite catalysed by manganese(III) acetylacetonate and moist alumina in dichloromethane

A solid-liquid biphasic system (dichloromethane and chromatographic neutral alumina) has been tested for the aromatic chlorination of various alkyl aryl ethers using a reagent combination of sodium chlorite and manganese(III) acetylacetonate catalyst. Efficient incorporation of a chlorine atom into the benzene ring with high para-selectivity results. This catalytic system is also applicable to the regiocontrolled chlorination of polyether substrates.