189950-17-2

Upstream product

• 50373-10-9 methyl ecgonidine 
• 18620-02-5 (4-bromophenyl)magnesium bromide 
• 17878-43-2 [4-(trimethylsilyl)phenyl]magnesium bromide 
• 174224-35-2 2β-carbomethoxy-3β-(4'-trimethylsilylphenyl)tropane 
• 135367-08-7 RTI 51 
• 303733-94-0 N-(2,2,2-trichloroethylcarbamoyl)-2β-carbomethoxy-3β-(4-bromophenyl)nortropane 

Downstream Products

• 1236307-81-5 C₁₉H₂₃Br⁽¹⁸⁾FNO₂ 
• 869845-29-4 N-(tert-butoxycarbonyl)-3β-(4'-(3-furyl)phenyl)nortropane-2β-carboxylic acid 
• 869845-28-3 3β-(4'-(3-furyl)phenyl)nortropane-2β-carboxylic acid 
• 910252-42-5 (1S,3S,4R,8R)-3-(4-Bromo-phenyl)-5-methylene-7-aza-tricyclo[5.3.0.0^4,8]decane 
• 910252-41-4 (1S,3S,4S,8R)-3-(4-Bromo-phenyl)-7-aza-tricyclo[5.3.0.0^4,8]decan-5-one 
• 910252-40-3 (1R,2S,3S,5S)-3-(4-Bromo-phenyl)-8-ethoxycarbonylmethyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester 
• 869845-23-8 2β-carbomethoxy-3β-(4'-(3-furyl)phenyl)nortropane 
• 674283-49-9 2β-carbomethoxy-3β-[4'-((Z)-2-bromoethenyl)phenyl]nortropane 

Relevant academic research and scientific papers

Synthesis and monoamine transporter affinity of front bridged tricyclic 3β-(4′-halo or 4′-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2β-position

A series of front bridged tricyclic 3β-(4′-halo or 4′-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2β-position was synthesized, and their binding affinities were determined in cells transfected to express human nor

Fluoralkenyl nortropanes

Provided are compounds of the following formula: wherein R is C2-C6 mono- or multi-unsaturated hydrocarbon having one or more ethylene, acetylene or allene groups, A is 18 or 19, and X is H or halogen. The compounds of the invention bind to dopamine transporter with high affinity and selectivity and are thus useful as diagnostic and therapeutic agents for diseases associated with dopamine transporter dysfunction. The radiolabeled compounds are useful as imaging agents for visualizing the location and density of dopamine transporter by PET imaging.

Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: Potential positron emission tomography (PET) imaging agents for the dopamine transporter

A series of novel fluoroalkyl-containing tropane derivatives was synthesized, and their binding affinities for the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET) were determined via competitive binding assays. Among these derivatives, the fluoropropyl ester of β-CIT (19), the fluoroethyl ester of β-CIT (20), the N-fluoropropyl derivative of β-CBT (12), and the fluoropropyl ester of β-CMT (18) displayed higher affinity and greater selectivity for the DAT versus SERT and NET than FP-CIT, which indicates that they are attractive candidates for the development of 18F-labeled PET imaging agents for the DAT.