18997-72-3

Usage

InChI:InChI=1/C6H14N2S2/c1-8(2)5-3-4-7-6(9)10/h3-5H2,1-2H3,(H2,7,9,10)

Upstream product

• 75-15-0 carbon disulfide 
• 109-55-7 1-amino-3-(dimethylamino)propane 

Downstream Products

• 27421-70-1 3-(dimethylamino)propyl isothiocyanate 
• 25952-53-8 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride 
• 1892-57-5 N-(3-dimethylaminopropyl)-N-ethylcarbodiimide 

Relevant academic research and scientific papers

PPAR-γ ligand —4, 5 -diazafluor - rhodanine conjugate as well as preparation method and anti-tumor application thereof

The invention discloses PPAR-γ ligand —4, 5 -diazafluor - rhodanine conjugate and a preparation method thereof, an anti-tumor application, 4, 5 -diazafluorene - rhodanine conjugates. The structure of R is YINQ - 1. , YINQ - 3 YINQ - 4. YINQ - 5 YINQ - 6 Y

Method for preparing isothiocyanate from ethyl chloroformate

The invention relates to a method for preparing isothiocyanate from ethyl chloroformate. The method comprises the following steps: taking a compound as shown in specification as a starting material, reacting with carbon disulfide to prepare inner salt, and then reacting the inner salt with ethyl chloroformate in an organic solvent at the temperature of 0-40 DEG C to prepare thio-mixed anhydride, wherein in the compound as shown in specification, n is 1, 2, 3, 4 or 5; and adding the mixed anhydride in an inorganic aqueous alkali, and hydrolyzing at the temperature of minus 5-30 DEG C to preparethe corresponding isothiocyanate. According to the preparation method, the mixed anhydride is synthesized at first, and then is hydrolyzed with inorganic alkali, application of organic alkali is avoided effectively, side reaction of the isothiocyanate and alcohol is relieved, and the reaction yield of the isothiocyanate and the purity of the product are improved.

1 - (3-dimethylamino-propyl) - 3-ethyl carbodiimide hydrochloride preparation method

The invention belongs to the field of organic chemical industry, and particularly relates to a preparation method of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride. The method comprises the following steps: enabling N,N'-dimethyl-1,3-propanediamine and carbon disulfide as raw materials to react in an organic solvent to generate an intermediate 1; enabling the intermediate 1 and ethyl chloroformate to react in the organic solvent, and preparing an intermediate 2 from triethylamine as an acid-binding agent; enabling the intermediate 2 and ethylamine to react in the organic solvent, so as to prepare an intermediate 3; adding a catalyst to the intermediate 3, oxidizing one time with an oxidant, so as to obtain a crude product 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, extracting and separating, so as to obtain an intermediate 4; and carrying out salt exchange reaction on the intermediate 4 and hydrochloride, so as to prepare the product 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride. The method has the advantages of relatively high conversion rate and relatively high total recovery rate and is simple to operate and suitable for industrial production.