190003-80-6

Upstream product

• 190003-78-2 1-(2',3'-di-O-acetyl-5'-O-benzoyl-β-D-xylofuranosyl)thymine 
• 769-78-8 vinyl benzoate 
• 52486-19-8 1-(β-D-xylofuranosyl)-thymine 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 98-88-4 benzoyl chloride 
• 115236-89-0 O³-acetyl-O⁵-benzoyl-O¹,O²-isopropylidene-α-D-xylofuranose 

Downstream Products

• 190003-84-0 1-(5'-O-benzoyl-2',3'-di-O-methylsulfonyl-β-D-xylofuranosyl)thymine 
• 190003-85-1 Benzoic acid (2R,3S,4R,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-bis-(toluene-4-sulfonyloxy)-tetrahydro-furan-2-ylmethyl ester 
• 122567-97-9 5′-benzoyl-2′,3′-didehydro-3′-deoxythymidine 
• 3056-17-5 stavudin 
• 190003-86-2 2,2'-anhydro-1-(5'-O-benzoyl-3'-O-methylsulfonyl-β-D-lyxofuranosyl)thymine 

Relevant academic research and scientific papers

Efficient and selective enzymatic acylation reaction: Separation of furanosyl and pyranosyl nucleosides

(Chemical Equation Presented) Candida antarctica lipase-B (CAL-B) immobilized on lewatite selectively acylated the primary hydroxyl group of the furanosyl nucleoside in a mixture of 1-(α-D-arabinofuranosyl)thymine and 1-(α-D-arabinopyranosyl)thymine. This selective biocatalytic acylation of furanosyl nucleoside has enabled us an easy separation of arabinofuranosyl thymine from an inseparable mixture with arabinopyranosyl thymine. The primary hydroxyl selective acylation methodology of arabinonucleoside has also been successfully used for the separation of 1-(β-D-xylofuranosyl)thymine and 1-(β-D-xylopyranosyl)thymine from a mixture of the two, which demonstrate the generality of the enzymatic methodology for separation of furanosyl and pyranosyl nucleosides.

Transformations of β-D-Xylofuranosyl Nucleosides. Synthesis of 3′-Deoxy-2′,3′-didehydrothymidine (D4T)

3′-Deoxy-2′,3′-didehydrothymidine was synthesized through a 10-step procedure starting from D-xylose. The overall yield of the target product was 28%.