190004-76-3Relevant academic research and scientific papers
Synthesis of metabolites of the cerebroprotecting agent 7-hydroxy-1- [[[4-(3-methoxyphenyl)-1-piperazinyl]acetyl]amino]-2,2,4,6-tetramethylindan (OPC-14117)
Otsubo, Kenji,Matsubara, Jun,Kitano, Kazuyoshi,Kawano, Yoshikazu,Ohtani, Tadaaki,Morita, Seiji,Sato, Seiji,Oshiro, Yasuo,Uchida, Minoru
, p. 728 - 732 (2007/10/03)
A hydroxylated metabolite (5a) of 7-hydroxy-1-[[[4-(3-methoxyphenyl)-1- piperazinyl]acetyl]amino]-2,2,4,6-tetramethylindan (OPC-14117), which is a novel cerebroprotective agent with central nervous system-stimulating activity, was synthesized by use of a model cytochrome P-450 system. In order to confirm the structure of this compound it was prepared by another route. The structures of several metabolites (5a, 7 and 8) were identified by means of comparisons with the synthetic compounds.
