190059-35-9Relevant academic research and scientific papers
Asymmetric synthesis of α-Amino acid derivatives via an electrophilic amination of chiral amide cuprates with Li t-Butyl-N-tosyloxycarbamate
Zheng, Nan,Armstrong III, Joseph D.,McWilliams, J. Christopher,Volante
, p. 2817 - 2820 (2007/10/03)
The utility of lithium t-butyl-N-tosyloxycarbamate (LiBTOC) as a (+)NHBOC synthon in highly diastereoselective reactions with chiral cis-aminoindanol derived amide cuprates is described. The diastereoselectivities of these reactions ranged from 96% to greater than 99%. The subsequent transformation of these adducts to α-amino acids is also described.
