1-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[(1R,2S)-1,2]-oxazol-3-yl)-2-phenylethanone

Base Information

• Chemical Name: 1-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[(1R,2S)-1,2]-oxazol-3-yl)-2-phenylethanone
• CAS No.: 190059-35-9
• Molecular Formula: C₂₀H₂₁NO₂
• Molecular Weight: 307.392

Synonyms:1-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[(1R,2S)-1,2]-oxazol-3-yl)-2-phenylethanone

Chemical Property of 1-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[(1R,2S)-1,2]-oxazol-3-yl)-2-phenylethanone

Chemical Property:

Purity/Quality:

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Technology Process of 1-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[(1R,2S)-1,2]-oxazol-3-yl)-2-phenylethanone

There total 2 articles about 1-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[(1R,2S)-1,2]-oxazol-3-yl)-2-phenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylacetyl chloride (103-80-0) → 1-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[(1R,2S)-1,2]-oxazol-3-yl)-2-phenylethanone (190059-35-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N

2: PPTS

With pyridinium p-toluenesulfonate; triethylamine;

DOI:10.1016/S0040-4039(97)00477-2

Reference yield:

2-Methoxypropene (116-11-0) + N-((1S,2R)-2-Hydroxy-indan-1-yl)-2-phenyl-acetamide → 1-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[(1R,2S)-1,2]-oxazol-3-yl)-2-phenylethanone (190059-35-9)

Guidance literature:

With pyridinium p-toluenesulfonate; Yield given;

DOI:10.1016/S0040-4039(97)00477-2

Reference yield: 51.0%

tert-butyl N-tosyloxycarbamate (105838-14-0) + 1-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[(1R,2S)-1,2]-oxazol-3-yl)-2-phenylethanone (190059-35-9) → [(S)-2-((3aS,8aR)-2,2-Dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-oxo-1-phenyl-ethyl]-carbamic acid tert-butyl ester (190059-42-8)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; -78 deg C; -78 deg C to 0 deg C; -78 deg C;

DOI:10.1016/S0040-4039(97)00477-2

upstream raw materials:

2-Methoxypropene

phenylacetyl chloride

Downstream raw materials:

[(S)-2-((3aS,8aR)-2,2-Dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-oxo-1-phenyl-ethyl]-carbamic acid tert-butyl ester

(S)-2-phenylglycine

(R)-phenylglycine

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