190083-97-7Relevant academic research and scientific papers
Synthesis of benzoylpyrimidines as antagonists of the corticotropin- releasing factor-1 receptor
Webb, Thomas R.,Moran, Terry,Huang, Charles Q.,McCarthy, James R.,Grigoriadis, Dimitri E.,Chen, Chen
, p. 3869 - 3873 (2007/10/03)
A series of benzoylpyrimidines derived from the anilinepyrimidine CRF 1 antagonists were synthesized. Several synthetic routes were developed to explore the SAR of this series of compounds. Compounds such as 8d (Ki=15nM) exhibited high binding affinities at the human CRF 1 receptor.
