76498-32-3

Upstream product

• 2418-31-7 (E)-2-methyl-but-2-enedioic acid diethyl ester 
• 76480-84-7 Potassium 2,5-Dimethyl-4-pyrimidine-6-carboxylate 
• 39875-10-0 2,5-Dimethyl-4-oxopyrimidine-6-carboxylic Acid 
• 74536-25-7 2,5-dimethylpyrimidine 
• 74536-25-7 Ethyl 2,5-Dimethyl-4-oxopyrimidine-6-carboxylate 
• 759-65-9 diethyl oxalpropionate 

Downstream Products

• 190084-80-1 (6-chloro-2,5-dimethyl-pyrimidin-4-yl)-(2,4,6-trimethyl-phenyl)-methanone 
• 76480-61-0 Ethyl 4-Amino-2,5-dimethylpyrimidine-6-carboxylate 
• 190084-03-8 [6-(cyclopropylmethyl-propyl-amino)-2,5-dimethyl-pyrimidin-4-yl]-(2,4,6-triethyl-phenyl)-methanone 
• 744253-31-4 [6-(cyclopropylmethyl-propyl-amino)-2,5-dimethyl-pyrimidin-4-yl]-(2,4,6-triethyl-phenyl)-methanol 
• 190084-04-9 cyclopropylmethyl-{2,5-dimethyl-6-[1-(2,4,6-trimethoxy-phenyl)-vinyl]-pyrimidin-4-yl}-propyl-amine 
• 744253-34-7 1-[6-(cyclopropylmethyl-propyl-amino)-2,5-dimethyl-pyrimidin-4-yl]-1-(2,4,6-trimethoxy-phenyl)-ethanol 
• 190083-97-7 [6-(cyclopropylmethyl-propyl-amino)-2,5-dimethyl-pyrimidin-4-yl]-(2,4,6-trimethoxy-phenyl)-methanone 
• 190084-00-5 [6-(cyclopropylmethyl-propyl-amino)-2,5-dimethyl-pyrimidin-4-yl]-(2,4,6-trimethyl-phenyl)-methanone 

Relevant academic research and scientific papers

NEW CCR2 RECEPTOR ANTAGONISTS AND USES THEREOF

The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.

NEW SELECTIVE CCR2 ANTAGONISTS

The present invention relates to novel and selective antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD as well as pain.

Synthesis of benzoylpyrimidines as antagonists of the corticotropin- releasing factor-1 receptor

A series of benzoylpyrimidines derived from the anilinepyrimidine CRF 1 antagonists were synthesized. Several synthetic routes were developed to explore the SAR of this series of compounds. Compounds such as 8d (Ki=15nM) exhibited high binding affinities at the human CRF 1 receptor.

Chemistry of 2-Substituted Pyrimidines. Studies Directed toward the Synthesis of the Pyrimidine Moiety of Bleomycin

Synthetic approaches to 2-substituted pyrimidines have been studied in an effort to facilitate the preparation of the pyrimidine moiety of bleomycin (2).Ethyl 2,5-dimethyl-4-oxopyrimidine-6-carboxylate (4) has been utilized as starting material; its conve