74536-25-7

Usage

Uses

Used in Medicinal and Pharmaceutical Research:
Ethyl 2,5-dimethyl-6-oxo-3,6-dihydropyrimidine-4-carboxylate is utilized as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure and properties contribute to its potential use in the treatment of a range of diseases and conditions, enhancing its value in drug development.

Upstream product

• 64-17-5 ethanol 
• 39875-10-0 2,5-Dimethyl-4-oxopyrimidine-6-carboxylic Acid 
• 759-65-9 diethyl oxalpropionate 
• 143-37-3 acetamidine 
• 124-42-5 acetamidine hydrochloride 
• 2418-31-7 (E)-2-methyl-but-2-enedioic acid diethyl ester 
• 76480-84-7 Potassium 2,5-Dimethyl-4-pyrimidine-6-carboxylate 

Downstream Products

• 76498-32-3 Ethyl 4-Chloro-2,5-dimethylpyrimidine-6-carboxylate 
• 76480-50-7 Ethyl 5-Methyl-2-(tribromomethyl)-4-oxopyrimidine-6-carboxylate 
• 190084-80-1 (6-chloro-2,5-dimethyl-pyrimidin-4-yl)-(2,4,6-trimethyl-phenyl)-methanone 
• 190084-00-5 [6-(cyclopropylmethyl-propyl-amino)-2,5-dimethyl-pyrimidin-4-yl]-(2,4,6-trimethyl-phenyl)-methanone 
• 190083-97-7 [6-(cyclopropylmethyl-propyl-amino)-2,5-dimethyl-pyrimidin-4-yl]-(2,4,6-trimethoxy-phenyl)-methanone 
• 744253-34-7 1-[6-(cyclopropylmethyl-propyl-amino)-2,5-dimethyl-pyrimidin-4-yl]-1-(2,4,6-trimethoxy-phenyl)-ethanol 
• 190084-04-9 cyclopropylmethyl-{2,5-dimethyl-6-[1-(2,4,6-trimethoxy-phenyl)-vinyl]-pyrimidin-4-yl}-propyl-amine 

Relevant academic research and scientific papers

Synthesis of benzoylpyrimidines as antagonists of the corticotropin- releasing factor-1 receptor

A series of benzoylpyrimidines derived from the anilinepyrimidine CRF 1 antagonists were synthesized. Several synthetic routes were developed to explore the SAR of this series of compounds. Compounds such as 8d (Ki=15nM) exhibited high binding affinities at the human CRF 1 receptor.

New Pyrimidino-Crown Ether Ligands

Eight new macrocyclic ligands containing the pyrimidine subcyclic unit (3-10 Figure 1) have been prepared.Two of these new crown ethers are chiral.Pyrimidino-crowns 3-8 were prepared by treating the ditosylate derivative of the appropriate oligoethylene glycol with 4-methoxy-5-methyl-2,6-pyrimidinedimethanol in basic conditions.The yields were in the 30-50percent range giving the crowns as viscous oils.Chiral dimethyl-substituted pyrimidino-crown 9 was prepared from 4-methoxy-5-methyl-2,6-pyrimidinedimethyl ditosylate and chiral dimethyl-substituted tetraethylene glycol.Treatment of dimethyl 4-methoxy-5-methyl-2,6-pyrimidinedicarboxylate with the diamine derivative of chiral dibenzyl-substituted tetraethylene glycol gave the chiral dibenzyl-substituted pyrimidino-crown diamide 10.Starting 4-methoxy-5-methyl-2,6-pyrimidinedimethanol was prepared by a six step process from acetamidine hydrochloride and diethyl oxalpropionate.

Chemistry of 2-Substituted Pyrimidines. Studies Directed toward the Synthesis of the Pyrimidine Moiety of Bleomycin

Synthetic approaches to 2-substituted pyrimidines have been studied in an effort to facilitate the preparation of the pyrimidine moiety of bleomycin (2).Ethyl 2,5-dimethyl-4-oxopyrimidine-6-carboxylate (4) has been utilized as starting material; its conve