190136-79-9Relevant academic research and scientific papers
Synthesis of functionalized epoxides by copper-catalyzed alkylative epoxidation of allylic alcohols with alkyl nitriles
Bunescu, Ala,Wang, Qian,Zhu, Jieping
, p. 1890 - 1893 (2015)
A copper-catalyzed oxyalkylation of allylic alcohols using nonactivated alkyl nitriles as reaction partners was developed. A sequence involving generation of an alkyl nitrile radical followed by its addition to a double bond and a copper-mediated formation of C(sp3)-O bond was proposed to account for the reaction outcome. The protocol provided an efficient route to functionalized tri- and tetrasubstituted epoxides via formation of a C(sp3)-C(sp3) and a C(sp3)-O bond with moderate to excellent diastereoselectivity.
A novel palladium-catalyzed asymmetric cyclocarbonylation of allylic alcohols to γ-butyrolactones
Yu, Wing-Yiu,Bensimon, Corinne,Alper, Howard
, p. 417 - 423 (2007/10/03)
A catalyst system based on [Pd2(dba)3]·CHCl3/(-)-BPPM has been found to effect asymmetric cyclocarbonylation of certain prochiral allylic alcohols to produce good yields of optically enriched γ-butyrolactones. The reaction
