190137-72-5

Upstream product

• 87234-28-4 1,3-dichloro-2-hydroxy-2-phenylpropane 
• 50-00-0 formaldehyd 
• 122-78-1 phenylacetaldehyde 
• 88-74-4 2-nitro-aniline 
• 5341-07-1 8-nitro-3-bromoquinoline 
• 98-80-6 phenylboronic acid 
• 497084-46-5 3-iodo-8-nitroquinoline 
• 607-35-2 8-nitroquinoline 

Downstream Products

• 190137-71-4 3-phenylquinolin-8-amine 
• 110746-01-5 3-phenyl-1,10-phenanthroline 

Relevant academic research and scientific papers

Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms

A series of 3-subsituted quinolinehydroxamic acids has been synthesised and evaluated for their effect on human lung cancer cell line (A549), human colorectal cancer cell line (HCT116) and HDAC isoforms 1, 2, 6, and 8. The results indicated that substitut

Direct synthesis of 3-arylquinolines by a nano Pd-catalyzed regioselective C3-H arylation of quinolines

3-Arylquinolines are biologically and medicinally very important compounds. Direct and regioselective C3-H arylation offers a straight forward methodology for their synthesis. In this work, we report their synthesis by a Pd nanoparticle catalyzed reaction

Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor

Poly(ADP-ribose)polymerase-1 is an important target enzyme in drug design; inhibitors have a wide variety of therapeutic activities. A series of quinoline-8-carboxamides was designed to maintain the required pharmacophore conformation through an intramolecular hydrogen bond. 3-Substituted quinoline-8-carboxamides were synthesized by Pd-catalyzed couplings (Suzuki, Sonogashira, Stille) to 3-iodoquinoline-8-carboxamide, an efficient process that introduces diversity in the final step. 2-Substituted quinoline-8-carboxamides were prepared by selective Pd-catalyzed couplings at the 2-position of 2,8-dibromoquinoline, followed by lithium-bromine exchange of the intermediate 2-(alkyl/aryl)-8-bromoquinolines and reaction with trimethylsilyl isocyanate. The intramolecular hydrogen bond was confirmed by X-ray and by NMR. The SAR of the 3-substituted compounds for inhibition of human recombinant PARP-1 activity showed a requirement for a small narrow group. Substituents in the 2-position increased potency, with the most active 2-methylquinoline-8-carboxamide having IC50 = 500 nM (IC50 = 1.8 μM for 5-aminoisoquinolin-1- one (5-AIQ, a standard water-soluble inhibitor)).

QUINOLINE COMPOUNDS AS H+-ATPASES

This invention relates to a quinoline compound of the formula: wherein R1 is a pyridyl group or aryl, each of which may be substituted with suitable substituent(s), A -COHN-or -NHCO-, n is an integer of 0 or 1, and is a group of the formula: In which R2, R3, R4, R5, R6 and R7 are as defined, and pharmaceutically acceptable salt thereof, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prevention and/or the treatment of bone diseases caused by abnormal bone metabolism in human being or animals.