87234-28-4

Usage

Uses

Used in Pharmaceutical Industry:
1,3-dichloro-2-phenylpropan-2-ol is used as an intermediate in the synthesis of various pharmaceuticals. It plays a crucial role in the production of certain drugs, contributing to the development of new medications.
Used in Pesticide Industry:
PCP-2-ol is utilized as an intermediate in the synthesis of pesticides. Its use in this industry helps in the development of effective pest control solutions to protect crops and maintain agricultural productivity.
Used in Organic Chemistry:
1,3-dichloro-2-phenylpropan-2-ol is used as a reagent in organic chemistry reactions. It aids in various chemical processes and contributes to the advancement of organic chemistry research and development.

Upstream product

• 513-88-2 1,1-Dichloroacetone 
• 75-16-1 methylmagnesium bromide 
• 108-86-1 bromobenzene 
• 534-07-6 1,3-Dichloroacetone 
• 591-50-4 iodobenzene 
• 593-71-5 Chloroiodomethane 
• 532-27-4 1-chloroacetophenone 
• 100-58-3 phenylmagnesium bromide 
• 591-51-5 phenyllithium 

Downstream Products

• 190137-72-5 8-nitro-3-phenylquinoline 
• 854652-59-8 2-hydroxy-2-phenyl-propane-1,3-disulfonic acid 
• 6006-81-1 3-hydroxy-2-phenylpropene 
• 1005-91-0 2-phenyl-2-(chloromethyl)oxirane 
• 141248-89-7 2-hydroxymethyl-2-phenyloxirane 
• 191479-39-7 3-chloro-2-phenyl-1,2-propanediol 

Relevant academic research and scientific papers

Synthesis of functional 1,2-dithiolanes from 1,3-bis-: Tert -butyl thioethers

We report the one-step synthesis of diversely substituted functional 1,2-dithiolanes by reacting readily accessible 1,3-bis-tert-butyl thioethers with bromine. The reaction proceeds to completion within minutes under mild conditions, presumably via a sulf

Organomagnesium Based Flash Chemistry: Continuous Flow Generation and Utilization of Halomethylmagnesium Intermediates

The generation of highly unstable chloromethylmagnesium chloride in a continuous flow reactor and its reaction with aldehydes and ketones is reported. With this strategy, chlorohydrins and epoxides were synthesized within a total residence time of only 2.6 s. The outcome of the reaction can be tuned by simply using either a basic or an acidic quench. Very good to excellent isolated yields, up to 97%, have been obtained for most cases (30 examples).

Enantioselective Cu(I)-Catalyzed Cycloaddition of Prochiral Diazides with Terminal or 1-Iodoalkynes

We report an unprecedented highly enantioselective desymmetric Cu(I)-catalyzed 1,3-dipolar cycloaddition of diazides with terminal alkynes and 1-iodoalkynes, affording tertiary alcohols bearing a 1,2,3-triazole moiety in high yield and excellent ee value. PYBOX ligands with a C4 shielding group once again show the promising ability to achieve higher enantioselectivity.

Asymmetric Desymmetrization via Metal-Free C?F Bond Activation: Synthesis of 3,5-Diaryl-5-fluoromethyloxazolidin-2-ones with Quaternary Carbon Centers

We disclose the first asymmetric activation of a non-activated aliphatic C?F bond in which a conceptually new desymmetrization of 1,3-difluorides by silicon-induced selective C?F bond scission is a key step. The combination of a cinchona alkaloid based ch

CiF bond activation of unactivated aliphatic fluorides: Synthesis of fluoromethyl-3,5-diaryl-2-oxazolidinones by desymmetrization of 2-aryl-1,3-difluoropropan-2-ols

How to lose fluorine: Biologically relevant oxazolidinones 1 were synthesized through the desymmetrization of unactivated aliphatic difluorides by Si-induced catalytic CiF bond-cleavage using BSA/CsF (BSA=bis(trimethylsilyl) acetamide). The direct transfo

An improved method for the addition reactions of 1,3-dichloroacetone with combined organolithium-cerium trichloride reagents

Alkyl-, phenyl- and alkynyllithium reagents in combination with anhydrous cerium(III) chloride underwent addition reactions with 1,3-dichloroacetone in a very efficient manner. The addition products are versatile precursors for 2-substituted epichlorohydrins and glycidols. Fluconazole, a potent antifungal agent, was thus synthesized in 67% yield by addition of 1,3-dichloroacetone to 2,4-difluorophenyllithium in the presence of cerium(III) chloride, followed by substitution of the chlorine atoms with 1,2,4-triazole.

Reactions of 2-substituted epichlorohydrins

2-Substituted epichlorohydrins have been synthesized by starting with 1,2-dichloro acetone and various alkyl and aryl halides via dichlorohydrins followed by cyclization. The reactive 2-substituted epichlorohydrins were subjected to nucleophilic attacking of azide and cyanide ions to afford corresponding β-azido alcohols and α,β-unsaturated nitriles.

Synthesis and Alkali-Metal Complexing Abilities of Crown Ether Tertiary Alcohols

Twenty-three crown ethers with a hydroxyl and an alkyl or aryl group linked directly to the central carbon of a three-carbon bridge were synthesized in one-step reactions of glycol and bisphenol dianions with substituted 2-(chloromethyl)oxiranes.Crown ether tertiary alcohols with methyl, n-decyl, n-tetradecyl, phenyl, and p-(n-decyl)phenyl substituents and four ring sizes are prepared.The effect of substituent on Na+ and K+ complexation is assessed by the picrate extraction method for closely related tertiary crown ether alcohols with 16-crown-5 and 15-crown-5-rings.

Synthesis and pharmacological study of aryloxypropanolamines substituted on carbon 2

In a series of aryloxypropanolamines, substitution on carbon 2 by alkyl, aryl or aralkyl groups lowers the β-blocking activity. This effect increases with the size of the substituent.