87234-28-4

Basic information

• Product Name: 1,3-dichloro-2-phenylpropan-2-ol
• CAS NO: 87234-28-4
• Molecular Formula: C₉H₁₀Cl₂O
• Molecular Weight: 205.0811
• Mol File: 87234-28-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 318.1°C at 760 mmHg
• Flash Point: 128.3°C
• Density: 1.282g/cm³
• Vapor Pressure: 0.000155mmHg at 25°C
• Refractive Index: 1.553
• CAS DataBase Reference: 1,3-dichloro-2-phenylpropan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-dichloro-2-phenylpropan-2-ol(87234-28-4)
• EPA Substance Registry System: 1,3-dichloro-2-phenylpropan-2-ol(87234-28-4)

Safety Data

• Hazardous Substances Data: 87234-28-4(Hazardous Substances Data)

Usage

General Description

1,3-dichloro-2-phenylpropan-2-ol, also known as PCP-2-ol, is a chemical compound with a molecular formula C9H10Cl2O. It is a colorless liquid with a slightly sweet odor that is used as an intermediate in the synthesis of pharmaceuticals and pesticides. PCP-2-ol is also used as a reagent in organic chemistry reactions. It is classified as a chlorinated alcohol and has been found to have some toxicological properties, including causing skin and eye irritation, and being harmful if ingested or inhaled. Additionally, it has been listed as a chemical of concern due to its potential health and environmental impacts.

Upstream product

• 593-71-5 Chloroiodomethane 
• 532-27-4 1-chloroacetophenone 
• 534-07-6 1,3-Dichloroacetone 
• 100-58-3 phenylmagnesium bromide 
• 591-51-5 phenyllithium 
• 591-50-4 iodobenzene 
• 108-86-1 bromobenzene 
• 513-88-2 1,1-Dichloroacetone 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 6006-81-1 3-hydroxy-2-phenylpropene 
• 1005-91-0 2-phenyl-2-(chloromethyl)oxirane 
• 876-43-7 1,3-difluoro-2-phenylpropan-2-ol 
• 1441287-78-0 1,3-difluoro-2-phenylpropan-2-yl N-phenylcarbamate 
• 1441287-96-2 1,3-difluoro-2-phenylpropan-2-yl N-(4-methylphenylcarbamate) 
• 1441287-98-4 1,3-difluoro-2-phenylpropan-2-yl N-(4-bromophenylcarbamate) 
• 1441288-04-5 5-fluoromethyl-3,5-diphenyloxazolidin-2-one 
• 1441288-26-1 5-fluoromethyl-3-(4-methylphenyl)-5-phenyloxazolidin-2-one 
• 1441288-30-7 3-(4-bromophenyl)-5-fluoromethyl-5-phenyloxazolidin-2-one 
• 1441288-35-2 5-fluoromethyl-3-(3-nitrophenyl)-5-phenyloxazolidin-2-one 
• 1441288-37-4 3-[3,5-bis(trifluoromethyl)phenyl]-5-fluoromethyl-5-phenyloxazolidin-2-one 
• 1441288-39-6 5-fluoromethyl-5-phenyl-3-tosyloxazolidin-2-one 
• 1441288-41-0 5-fluoromethyl-3,5-diphenyloxazolidin-2-thione 

Relevant articles and documents

Organomagnesium Based Flash Chemistry: Continuous Flow Generation and Utilization of Halomethylmagnesium Intermediates

The generation of highly unstable chloromethylmagnesium chloride in a continuous flow reactor and its reaction with aldehydes and ketones is reported. With this strategy, chlorohydrins and epoxides were synthesized within a total residence time of only 2.6 s. The outcome of the reaction can be tuned by simply using either a basic or an acidic quench. Very good to excellent isolated yields, up to 97%, have been obtained for most cases (30 examples).

Synthesis of functional 1,2-dithiolanes from 1,3-bis-: Tert -butyl thioethers

We report the one-step synthesis of diversely substituted functional 1,2-dithiolanes by reacting readily accessible 1,3-bis-tert-butyl thioethers with bromine. The reaction proceeds to completion within minutes under mild conditions, presumably via a sulf

CiF bond activation of unactivated aliphatic fluorides: Synthesis of fluoromethyl-3,5-diaryl-2-oxazolidinones by desymmetrization of 2-aryl-1,3-difluoropropan-2-ols

How to lose fluorine: Biologically relevant oxazolidinones 1 were synthesized through the desymmetrization of unactivated aliphatic difluorides by Si-induced catalytic CiF bond-cleavage using BSA/CsF (BSA=bis(trimethylsilyl) acetamide). The direct transfo