19016-83-2

Basic information

• Product Name: Benzene, (4-methyl-3-penten-1-ynyl)-
• Synonyms: 4-Methyl-1-phenyl-3-penten-1-yne;(4-methylpent-3-en-1-ynyl)benzene;1-Phenylpent-3-en-1-yne;Benzene,(4-methyl-3-penten-1-ynyl)
• CAS NO: 19016-83-2
• Molecular Formula: C12H12
• Molecular Weight: 156.227
• Mol File: 19016-83-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzene, (4-methyl-3-penten-1-ynyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, (4-methyl-3-penten-1-ynyl)-(19016-83-2)
• EPA Substance Registry System: Benzene, (4-methyl-3-penten-1-ynyl)-(19016-83-2)

Safety Data

• Hazardous Substances Data: 19016-83-2(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 127704-41-0 (Z)-2-Bromo-4-methyl-1-phenyl-1,3-pentadiene 
• 160721-89-1 (Z)-2-Chloro-4-methyl-1-phenyl-1,3-pentadiene 
• 102-96-5 (2-nitroethenyl)benzene 
• 33603-89-3 (Z)-2-chloro-3-phenyl-2-propenal 
• 33603-90-6 (2Z)-2-bromo-3-phenyl-2-propenal 
• 870-63-3 prenyl bromide 
• 15874-80-3 3-methyl-1-(phenylsulfonyl)but-2-ene 
• 4440-01-1 lithium phenylacetylide 
• 88958-78-5 C₁₈H₁₈O₂S 
• 2579-22-8 Phenylpropargyl aldehyde 
• 1530-33-2 isopropyltriphenylphosphonium bromide 
• 513-37-1 2-methylprop-1-enyl chloride 
• 536-74-3 phenylacetylene 

Downstream Products

• 1286793-63-2 2-(4-methyl-1-phenylpenta-1,3-dien-2-yl)-(Z)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 23675-67-4 (4-methylpent-4-en-1-yn-1-yl)benzene 
• 124475-76-9 2-(2,2-Dimethyl-3-phenylethynyl-aziridin-1-yl)-isoindole-1,3-dione 

Relevant articles and documents

Unprecedented Mechanism of an Organocatalytic Route to Conjugated Enynes with a Junction to Cyclic Nitronates

Conjugated enynes as well as cyclic nitronates are crucial building blocks for numerous natural products and pharmaceuticals. However, so far, no common and metal-free synthetic route to both conjugated enynes and cyclic nitronates has been reported. Herein, in situ NMR, labelling studies and theoretical calculations were combined to investigate the mechanism of the unusual triple bond formation towards conjugated enynes. Starting from nitroalkene dimers, first an isoxazolidine-2,5-diol derivative is formed as central intermediate. From this, enynes were generated by a combination of oxidation, dehydration, and retro 1,3-dipolar cycloaddition, whereas for nitronates a base induced intramolecular reorganization is proposed. While the product distribution could be controlled and high yields of nitronate were achieved, only medium to good yields for enynes were obtained due to polymerization losses. Nevertheless, we hope that these mechanistic investigations may provide a basis for further developments of organocatalytic or metal-free preparations of conjugated enynes and nitronates.

Integrated Chemical Process: One-Pot Double Elimination Method for Acetylenes

A novel one-pot process for synthesis of acetylenes has been achieved in which the following series of steps are integrated: addition of an α-anion of sulfone to aldehyde; trapping of the resulting adduct to incorporate a leaving group, and double elimination of this intermediate. Consolidation of Peterson elimination renders the process much simpler. This method provides a convenient and high-yielding access to a variety of enynes and polyynes as well as to functionally substituted aryl acetylenes containing halogen(s) or acetal groups, which are useful building blocks for aryl acetylene scaffolds. Iteration of the one-pot generation of acetylenic bonds provides a new metodology for the buildup of aryl acetylene skeletons.

Reactions of propargyl metallic species generated by the addition of alkynyllithiums to Fischer-type carbene complexes

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