19018-01-0Relevant academic research and scientific papers
A Facile Oxidation of Tertiary Amines to Lactams by Using Sodium Chlorite: Process Improvement by Precise pH Adjustment with CO 2
Liu, Chaoyang,Sun, Haozhou,Qin, Cheng,Yang, Tiannuo,Zhang, Wenxian,Zhou, Yuan,Li, Yani,Jia, Zheng Robert,Chu, Changhu
, p. 993 - 997 (2022/05/17)
By using cheap and innocuous sodium chlorite, a series of tertiary amines have been oxidized to the corresponding lactams with good selectivity and high yield. In this method, neither transition-metal catalyst nor oxidant was used. In the oxidation step, the pH of the sodium chlorite was precisely adjusted to pH around 6 using CO2, such pH is a compromise between oxidative properties, chemical stability, and unwanted precipitation. In addition, buffer salts are not necessary, which allows this oxidation reaction to be performed under safe and environmentally benign conditions.
Synthesis of 2,3-dihydro-4(1H)-quinolones and the corresponding 4(1H)-quinolones via low-temperature fries rearrangement of N-arylazetidin-2- ones
Lange, Jens,Bissember, Alex C.,Banwell, Martin G.,Cade, Ian A.
experimental part, p. 454 - 470 (2011/10/09)
N-Arylazetidin-2-ones of the general form 1, which are readily prepared by GoldbergBuchwald-type copper-catalyzed coupling of N-unsubstituted azetidin-2-ones with the relevant aryl halide or using Mitsunobu cyclization processes, undergo smooth Fries-rearrangement in triflic acid at 018°C to give the isomeric 2,3-dihydro-4(1H)-quinolones (2). Dehydrogenation of the latter compounds using 10% Pd on C in 1.0M aqueous sodium hydroxide/propan-2-ol mixtures at ca. 82°C provides the corresponding 4(1H)-quinolones (3).
A Convenient Synthesis of Monocyclic β-Lactams by Means of Solid-Liquid Phase Transfer Reactions
Takahata, Hiroki,Ohnishi, Yoshinori,Takehara, Hiroyuki,Tsuritani, Kazuko,Yamazaki, Takao
, p. 1063 - 1068 (2007/10/02)
The intramolecular N-alkylation of β-bromopropionamides (1) under phase transfer conditions afforded monocyclic N-substituted β-lactams (2) in high yields.In a similar manner, cyclization by N1-C4 bond formation gave 4-benzoyl-2-azet
A CONVENIENT SYNTHESIS OF MONOCYCLIC β-LACTAMS
Takahata, Hiroki,Ohnishi, Yoshinori,Yamazaki, Takao
, p. 467 - 469 (2007/10/02)
The intramolecular N-alkylation of β-bromopropionamide (1) under phase transfer conditions gave monocyclic β-lactams (2) in high yields.
