190182-12-8

Upstream product

• 22192-21-8 4-Chlorbenzyltriphenylphosphoniumchlorid 
• 90-02-8 salicylaldehyde 
• 4846-21-3 O-phenylhydroxylamine 
• 64908-64-1 2-phenoxyisoindol-1,3-dione 
• 1073-67-2 4-vinylbenzyl chloride 
• 5661-50-7 N-(phenoxy)acetamide 
• 98-80-6 phenylboronic acid 

Downstream Products

• 127003-34-3 2-(3-dimethylaminopropoxy)-4'-chlorobibenzyl 
• 167145-38-2 2-[2-(4-chlorophenyl)ethyl]phenol 

Relevant academic research and scientific papers

Rhodium(III)-catalyzed C-H olefination for the Synthesis of ortho-alkenyl phenols using an oxidizing directing group

By using an oxidizing directing group, a mild, efficient Rh(III) catalyzed C-H olefination reaction between N-phenoxyacetamides and alkenes was developed. This reaction provided a straightforward way for the synthesis of ortho-alkenyl phenols, and the directing group is traceless in the product.

Syntheses and Platelet Aggregation Inhibitory and Antithrombotic Properties of ethyl>benzenes

A series of ethyl>benzene derivatives were synthesized and evaluated for their ability to inhibit collagen-induced platelet aggregation in vitro and to protect experimantal thrombosis in mice.The results showed that the compounds were in vitro inhibitors of collagen-induced platelet aggregation.Most of them were also effective in the mouse antithrombotic assay.The compounds were found to be potent antagonists to S2 serotonergic receptor, and good correlation (r = 0.85) between their S2 serotonergic receptor antagonism and their potency as platelet antiaggregatory drugs was observed.Among the compounds studied, monophenoxy>methyl>ethyl>succinate hydrochloride (12b, MCI-9042) was selected for further pharmacological and toxicological evaluation.