190202-99-4Relevant academic research and scientific papers
Bioreversible oligonucleotide conjugates by site-specific derivatization
Iyer, Radhakrishnan P.,Ho, Nan-Hui,Yu, Dong,Agrawal, Sudhir
, p. 871 - 876 (1997)
Oligonucleotide analogs which are site-specifically derivatized with O-acyloxyaryl groups were prepared using phosphoramidite chemistry. Upon their incubation with pig liver esterase (PLE) or chymotrypsin, the analogs were shown to revert to the parent compound.
