Bioreversible oligonucleotide conjugates by site-specific derivatization

DOI: 10.1016/S0960-894X(97)00119-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 871 - 876 (1997)

Update date:2022-08-16

Topics:

Authors:

Iyer, Radhakrishnan P.

Ho, Nan-Hui

Yu, Dong

Agrawal, Sudhir

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Article abstract of DOI:10.1016/S0960-894X(97)00119-4

Oligonucleotide analogs which are site-specifically derivatized with O-acyloxyaryl groups were prepared using phosphoramidite chemistry. Upon their incubation with pig liver esterase (PLE) or chymotrypsin, the analogs were shown to revert to the parent compound.

Full text of DOI:10.1016/S0960-894X(97)00119-4

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