190256-56-5

Upstream product

• 43050-16-4 1-(4-methoxyphenyl)-1,2-epoxycyclohexane 
• 74-88-4 methyl iodide 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 765-87-7 cyclohexane-1,2-dione 
• 20758-60-5 1-(4-methoxyphenyl)cyclohexene 

Downstream Products

• 190256-71-4 (R)-2-(4-methoxyphenyl)cyclohexan-1-one 
• 1070898-79-1 C₂₃H₃₄N₂O₆ 

Relevant academic research and scientific papers

Selective Carbonyl?C(sp3) Bond Cleavage To Construct Ynamides, Ynoates, and Ynones by Photoredox Catalysis

Carbon–carbon bond cleavage/functionalization is synthetically valuable, and selective carbonyl?C(sp3) bond cleavage/alkynylation presents a new perspective in constructing ynamides, ynoates, and ynones. Reported here is the first alkoxyl-radical-enabled carbonyl?C(sp3) bond cleavage/alkynylation reaction by photoredox catalysis. The use of novel cyclic iodine(III) reagents are essential for β-carbonyl alkoxyl radical generation from β-carbonyl alcohols, including alcohols with high redox potential (EoxP>2.2 V vs. SCE in MeCN). β-Amide, β-ester, and β-ketone alcohols yield ynamides, ynoates, and ynones, respectively, for the first time, with excellent regio- and chemoselectivity under mild reaction conditions.

Enantioselective protonation of samarium enolates derived from α- heterosubstituted ketones and lactone by SmI2-mediated reduction

SmI2-mediated reductive cleavage of α-heterosubstituents of α-alkyl or α-aryl ketones and lactone gave the corresponding 'thermodynamic samarium enolates'. Enantioselective protonation of the samarium enolates with C2- symmetric chiral diols afforded the corresponding ketones and lactone in moderate to high enantioselectivities.