190271-78-4

Upstream product

• 4885-02-3 Dichloromethyl methyl ether 
• 35826-59-6 methyl 4-isopropoxybenzoate 
• 75-30-9 2-iodo-propane 
• 24589-99-9 methyl 3-formyl-4-hydroxybenzoate 

Downstream Products

• 1312312-22-3 C₁₆H₂₀O₅ 
• 213598-11-9 methyl 3-cyano-4-[(1-methylethyl)oxy]benzoate 
• 1346498-74-5 3-(hydroxymethyl)-4-isopropoxy-benzoic acid 
• 1346498-73-4 methyl 3-(hydroxymethyl)-4-isopropoxy-benzoate 
• 1289061-37-5 3-formyl-4-isopropoxy-benzoic acid 
• 918870-83-4 methyl 4-isopropoxy-3-vinylbenzoate 
• 1312312-24-5 4-(4-isopropoxy-3-vinylbenzyloxy)-4-oxobutanoic pivalic anhydride 

Relevant academic research and scientific papers

3-cyano-4-alcoholate benzoate synthesis method

The invention discloses a 3-cyano-4-alcoholate benzoate synthesis method. The general formula for the reaction is shown in the description, wherein R1 is isopropyl or other alkyls, and R2 is alkyl. The reaction condition of the method is mild, the raw materials are easy to get, the yield is high, the post-processing is simple, and the method provides an important reference for the industrial production.

PYRAN-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS

The invention relates to pyran spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the composition

CHROMAN - SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS

The invention relates to chroman spirocyclic piperidine amide derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

PYRROLOPYRAZINE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS

The invention relates to pyrrolopyrazine-spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Synthesis of (+)-dumetorine and congeners by using flow chemistry technologies

An efficient total synthesis of the natural alkaloid (+)-dumetorine by using flow technology is described. The process entailed five separate steps starting from the enantiopure (S)-2- (piperidin-2-yl)ethanol 4 with 29 % overall yield. Most of the reactio