190328-69-9

Basic information

• Product Name: methyl 4,7-dimethoxy-1-benzothiophene-2-carboxylate
• Synonyms: Methyl-4,7-dimethoxy-1-benzothiophen-2-carboxylat
• CAS NO: 190328-69-9
• Molecular Formula: C₁₂H₁₂O₄S
• Molecular Weight: 252.2863
• Mol File: 190328-69-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 388.775°C at 760 mmHg
• Flash Point: 188.925°C
• Density: 1.268g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: methyl 4,7-dimethoxy-1-benzothiophene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4,7-dimethoxy-1-benzothiophene-2-carboxylate(190328-69-9)
• EPA Substance Registry System: methyl 4,7-dimethoxy-1-benzothiophene-2-carboxylate(190328-69-9)

Safety Data

• Hazardous Substances Data: 190328-69-9(Hazardous Substances Data)

Upstream product

• 1483-27-8 2,5-dimethoxythiophenol 
• 1649501-99-4 methyl 2-(2,5-dimethoxyphenylthio)acetate 
• 1649501-86-9 methyl (Z)-2-(2,5-dimethoxyphenylthio)-3-(dimethylamino)acrylate 
• 1206-55-9 3,6-dimethoxy-2-nitrobenzaldehyde 
• 2365-48-2 Methyl thioglycolate 

Relevant articles and documents

Synthesis and antitumor evaluation of thiophene analogs of kigelinone

The synthesis of kigelinone thiophene analogs and related naphtho[2,3-b]thiophene-4,9-quinones from 2-substituted 4,7-dimethoxybenzo[b] thiophenes via an oxidative deprotection, Diels-Alder, and oxidative aromatization reaction sequence is reported. The 2-substituted naphtho[2,3-b]thiophene-4,9-quinones display significant antitumor activity in the range IC50 1.1-47 μM on a panel of four distinct human cancer cell lines.

Synthesis and antifungal activity of 5-arylamino-4,7-dioxobenzo[b] thiophenes

5-Arylamino-4,7-dioxobenzo[b]thiophenes 3-6 were synthesized and tested for in vitro antifungal activity against Candida and Aspergillus species. 5-Arylamino-6-chloro-2-(methoxycarbonyl)-4,7-dioxobenzo[b]thiophenes 5 showed, in general, more potent antifungal activity against Candida species than the other 4,7-dioxobenzo[b]thiophenes 3, 4 and 6. The results suggest that 5-arylamino-4,7-dioxobenzo[b]thiophenes would be potent antifungal agents.

NEW TRICYCLIC QUINONE DERIVATIVE

This invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof. Specifically, the present invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof [Therein, A is O,

Solvent-free microwave synthesis of 3-(4-benzo[b]-thiophene-2-carbonyl)-1-piperazinyl-1-benzo[b]thiophen-2-YL-1-propanones. New hetero bis-ligands with potential 5-HT1A serotonergic activity

A novel series of 2-benzothiophenealkylpiperazine derivatives 11 (a-d) with potential affinity at 5-HT1A serotonin receptors have been synthesized via solvent-free, microwave-promoted Michael addition of benzo[b]thiophene piperazine derivatives 6(a-c) to substituted benzo[b]thiophen-2-yl propenones 10(b,c).