190328-69-9

Upstream product

• 1483-27-8 2,5-dimethoxythiophenol 
• 1649501-99-4 methyl 2-(2,5-dimethoxyphenylthio)acetate 
• 1649501-86-9 methyl (Z)-2-(2,5-dimethoxyphenylthio)-3-(dimethylamino)acrylate 
• 1206-55-9 3,6-dimethoxy-2-nitrobenzaldehyde 
• 2365-48-2 Methyl thioglycolate 

Downstream Products

• 190328-71-3 4,7-dimethoxy-benzo[b]thiophene-2-carboxylic acid 
• 899833-28-4 5-[(2-acetylphenyl)amino]-1-benzo[b]thiophene-4,7-dione 
• 73630-87-2 benzothiophene-4,7-quinone 

Relevant academic research and scientific papers

Synthesis and antitumor evaluation of thiophene analogs of kigelinone

The synthesis of kigelinone thiophene analogs and related naphtho[2,3-b]thiophene-4,9-quinones from 2-substituted 4,7-dimethoxybenzo[b] thiophenes via an oxidative deprotection, Diels-Alder, and oxidative aromatization reaction sequence is reported. The 2-substituted naphtho[2,3-b]thiophene-4,9-quinones display significant antitumor activity in the range IC50 1.1-47 μM on a panel of four distinct human cancer cell lines.

Synthesis of 2-benzothienyl carbonyl 4-arylpiperazines as novel delavirdine analogs

A novel series of 2-benzothienyl carbonyl arylpiperazines (6a-f) was synthesized as potential HIV nonnucleoside reverse transcriptase inhibitors (NNRTIs). Preparation of the derivatives was performed by reacting benzo[b]thiophene carbonyl chloride (5) wit

Synthesis and antifungal activity of 5-arylamino-4,7-dioxobenzo[b] thiophenes

5-Arylamino-4,7-dioxobenzo[b]thiophenes 3-6 were synthesized and tested for in vitro antifungal activity against Candida and Aspergillus species. 5-Arylamino-6-chloro-2-(methoxycarbonyl)-4,7-dioxobenzo[b]thiophenes 5 showed, in general, more potent antifungal activity against Candida species than the other 4,7-dioxobenzo[b]thiophenes 3, 4 and 6. The results suggest that 5-arylamino-4,7-dioxobenzo[b]thiophenes would be potent antifungal agents.

Studies on quinones: Part 30. Synthesis of benzo[b]thiophene-4,7- quinones

The synthesis of a variety of benzo[b]thiophene-4,7-quinones (4a-f) by oxidative demethylation of the corresponding 4,7-dimethoxybenzo[b]thiophenes (3a-f) with cerium (IV) ammonium nitrate is reported. Heterocycles (3a,b) were prepared by cyclization of t

NEW TRICYCLIC QUINONE DERIVATIVE

This invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof. Specifically, the present invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof [Therein, A is O,

Efficient synthetic approach to substituted benzo[b]furans and benzo[b]thiophenes by iodine-promoted cyclization of enaminones

An efficient synthetic approach to the substituted benzo[b]furan and benzo[b]thiophene scaffolds by iodine-mediated cyclization of the corresponding enaminones is described. This protocol was applied to a large series of these latter precursors to afford the respective benzoheterocycles substituted at the C-2 position by a carbonyl group functionality. A study of the factors that control this process reveals that the reactivity depends on the presence of electron-donor groups in the aryl ring of the aryloxycarbonylic and arylthiocarbonylic moieties.

Solvent-free microwave synthesis of 3-(4-benzo[b]-thiophene-2-carbonyl)-1-piperazinyl-1-benzo[b]thiophen-2-YL-1-propanones. New hetero bis-ligands with potential 5-HT1A serotonergic activity

A novel series of 2-benzothiophenealkylpiperazine derivatives 11 (a-d) with potential affinity at 5-HT1A serotonin receptors have been synthesized via solvent-free, microwave-promoted Michael addition of benzo[b]thiophene piperazine derivatives 6(a-c) to substituted benzo[b]thiophen-2-yl propenones 10(b,c).

Synthesis of benzo[b]thiophene carboxamides connected to 4-arylpiperazines through a benzylic spacer: Potential ligands with 5-HT1A binding affinity

New benzothiophene arylpiperazine derivatives 8 (a-f) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by treating N-[2-(chloromethyl)phenyl]-4,7- dimethoxybenzo[b]thiophene-2-