190334-09-9

Upstream product

• 40254-89-5 3-chloro-2-quinoxalinecarbonitrile 
• 160315-00-4 ethyl 2-acetate 
• 103-72-0 phenyl isothiocyanate 
• 190334-07-7 3-Amino-1H-pyrrolo[2,3-b]quinoxaline-2-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis of New Triazoloquinoxalines, Pyrroloquinoxalines, and Pyrimidopyrroloquinoxalines

When 2-hydroxyquinoxaline-3-carboxamide (1) was reacted with POCl3 in DMF, 2-chloro-3-dimethylaminomethylenecarboxamide(2) was obtained. The chloro compound 2 was reacted with thiourea and hydrazine hydrate to give the corresponding mercapto and hydrazino derivatives 3 and 8, respectively. On the other hand, 2-chloroquinoxaline-3-carbonitrile (13) reacted with ethyl glycinate to the glycinate derivative 14 which was cyclized to pyrroloquinoxaline 15 by heating with sodium ethoxide. Pyrimidopyrroloquinoxaline derivatives 16 and 17 were obtained via the reaction of 15 with formamide and phenyl isothiocyanate, respectively.

Synthesis of new triazoloquinoxalines, pyrroloquinoxalines and pyrimidopyrroloquinoxalines

When 2-hydroxyquinoxaline-3-carboxamide (1) was subjected to react with POCl3 in DMF, 2-chloro-3-dimethylaminomethylenecarboxamide (2) was obtained. The chloro compound 2 was reacted with thiourea and hydrazine hydrate to give the corresponding mercapto and hydrazino derivatives 3 and 8, respectively. On the other hand, 2-chloroquinoxaline-3-carbonitrile (13) was reacted with ethyl glycinate to give the glycinate derivative 14, which was cyclized into pyrroloquinoxaline 15 by heating with sodium ethoxide. Pyrimidopyrroloquinoxaline derivatives 16, and 17 were obtained by reaction of 15 with formamide and phenyl isothiocyanate respectively.