Synthesis of New Triazoloquinoxalines, Pyrroloquinoxalines, and Pyrimidopyrroloquinoxalines

Article abstract of DOI:10.1007/BF00807794

When 2-hydroxyquinoxaline-3-carboxamide (1) was reacted with POCl₃ in DMF, 2-chloro-3-dimethylaminomethylenecarboxamide(2) was obtained. The chloro compound 2 was reacted with thiourea and hydrazine hydrate to give the corresponding mercapto and hydrazino derivatives 3 and 8, respectively. On the other hand, 2-chloroquinoxaline-3-carbonitrile (13) reacted with ethyl glycinate to the glycinate derivative 14 which was cyclized to pyrroloquinoxaline 15 by heating with sodium ethoxide. Pyrimidopyrroloquinoxaline derivatives 16 and 17 were obtained via the reaction of 15 with formamide and phenyl isothiocyanate, respectively.