40254-89-5Relevant academic research and scientific papers
Synthesis and antituberculosis activity of some new 2-quinoxalinecarbonitriles.
Montoya,Sainz,Ortega,Lopez De Cerain,Monge
, p. 570 - 573 (1998)
Tuberculosis, an ancient disease undergoing recent control by public hygiene and drug therapy, has experienced a recrudescence throughout the world. New and effective therapies are rapidly needed to combat infections caused by these strains. Some new 2-quinoxalinecarbonitriles have been synthesized and tested as antituberculosis agents and interesting results have been obtained from the first screening.
3-Amino-2-quinoxalinecarbonitrile. New fused quinoxalines with potential cytotoxic activity
Monge,Palop,Pinol,Martinez-Crespo,Narro,Gonzalez,Sainz,Lopez De Cerain,Hamilton,Barker
, p. 1135 - 1139 (2007/10/02)
Starting with 3-amino-2-quinoxalinecarbonitrile 1,4-dioxide 1, a new series of quinoxaline derivatives was prepared through chemical modifications of the 2-cyano and 3-amino groups. Nitration of 3-amino-2-quinoxalinecarbonitrile 3 afforded the 7-nitro derivative 6. Diazotation of 3 gave the 3-chloro compound 9. 2,3-Quinoxalinedicarbonitrile 14 was obtained from 9. Pyridazino[4,5-b]quinoxalines 15 and 16 were prepared by condensing 14 with hydrazine hydrate. A triazolo[4,5-b]quinoxaline 18, a isothiazolo[4,5-b]quinoxaline 20 and two pyrazolo[3,4-b]quinoxalines 21 and 22 were identified. Compounds were tested as cytotoxic agents both in oxic and in hypoxic cells.
Novel Antagonists of 5-HT3 Receptors. Synthesis and Biological Evaluation of Piperazinylquinoxaline Derivatives
Monge, A.,Palop, J. A.,Castillo, J. C. Del,Caldero, J. M.,Roca, J.,et al.
, p. 2745 - 2750 (2007/10/02)
A series of piperazinylquinoxalines has been synthesized and studied as 5-HT3 receptor antagonists in different preparations.Antagonism to 5-HT in the longitudinal muscle of the guinea pig ileum was particularly prominent in cyanoquinoxaline de
Quinoxalines. XXVII. The cyanation of 2-substituted quinoxaline 4-oxides with trimethylsilyl cyanide
Iijima,Miyashita
, p. 661 - 663 (2007/10/02)
The deoxy-cyanation of 2-substituted quinoxaline 4-oxides (1a--k) with trimethylsilyl cyanide in the presence of 1,8-diazabicyclo[5.4.0.]undec-7-ene gave the corresponding 3-substituted 2-quinoxalinecarbonitriles (IIa--k). However, in the case of 2-(p-tol
Synthesis of Condensed Quinoxalines. VI. Synthesis of 1H-Pyrazoloquinoxaline N-Oxides and Related Compounds
Yoshida, Kei,Otomasu, Hirotaka
, p. 3361 - 3365 (2007/10/02)
Oxidation of 1H-pyrazoloquinoxalines (1a: R=H, 1b: R=CH3) with m-chloroperbenzoic acid (MCPBA) gave the 4-oxides (2a, b).The structures of 2a, b were confirmed by synthesis, by condensing 2-chloroquinoxaline-3-carbaldehyde 4-oxide (6) with appropri
