1904-65-0

Basic information

• Product Name: 2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE
• Synonyms: 2,3,4,5-TETRAHYDRO-(1H)-1,4-BENZODIAZEPINE;2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE
• CAS NO: 1904-65-0
• Molecular Formula: C₈H₁₀N₂
• Molecular Weight: 148.2
• Product Categories: pharmacetical
• Mol File: 1904-65-0.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE(1904-65-0)
• EPA Substance Registry System: 2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE(1904-65-0)

Safety Data

• Hazardous Substances Data: 1904-65-0(Hazardous Substances Data)

Usage

General Description

2,3,4,5-Tetrahydro-1H-benzo[e][1,4]diazepine, also known as THBD, is a chemical compound with a molecular formula of C11H12N2. It is a heterocyclic compound that contains a seven-membered diazepine ring fused to a benzene ring. THBD has been studied for its potential application as a pharmaceutical drug, with research indicating that it may possess anxiolytic and anticonvulsant properties. Additionally, THBD has been investigated as a potential ligand for binding with GABA receptors in the brain. The compound's structure and chemical properties make it an intriguing target for further research and development in the field of medicinal chemistry.

Upstream product

• 253-82-7 quinazoline 
• 1904-64-9 3,4-dihydroquinazoline 
• 7732-18-5 water 
• 22820-08-2 3,4-dihydro-1H-quinazoline-2-thione 
• 64-17-5 ethanol 
• 50-00-0 formaldehyd 
• 4403-69-4 2-amino-1-benzylamine 
• 3398-07-0 2-aminobenzaldehyde oxime 
• 32907-43-0 quinazoline-N-oxide 
• 53378-34-0 1,2-dihydro-quinazoline 

Downstream Products

• 1415460-56-8 3-(2-iodobenzyl)-1,2,3,4-tetrahydroquinazoline 
• 40132-09-0 3-benzyl-1,2,3,4-tetrahydro-quinazoline 
• 253-82-7 quinazoline 

Relevant articles and documents

Cu-Catalyzed Chemoselective Reduction of N-Heteroaromatics with NH3·BH3 in Aqueous Solution

An efficient catalytic system was successfully developed on reduction of N-heteroaromatics with H3N?BH3 as hydrogen source in CuSO4 solution, featuring excellent chemoselectivity as well as very broad functional group tolerance. Various challenging substrates, such as OH-, NH2-, Cl-, Br-, etc., contained quinolines, quinoxalines, 1,5-naphthyridines and quinazolines were all reduced smoothly. Mechanistic studies suggested that [Cu-H] intermediate might be generated from NH3?BH3, which was believed to form with H3N?BH3 in CuSO4 solution.

Chemoselective hydrogenation of heteroarenes and arenes by Pd-Ru-PVP under mild conditions

Monometallic (Pd, Ru or Rh) and bimetallic (Pd0.5-Ru0.5) alloy NPs catalysts were examined for the hydrogenation of quinoline. Pd-Ru alloy catalyst showed superior catalytic activity to the traditional Rh catalyst. The characterization of Pd0.5-Ru0.5 catalysts, HAADF-EDX mapping and XPS analysis suggested that the alloy state of PdRu catalysts remained unchanged in the recovered catalyst. Furthermore, the catalyst was highly selective for the hydrogenation of different arenes. This journal is

Gold(0) catalyzed dehydrogenation of N-heterocycles

Gold nanoclusters are good catalyst precursors for the catalytic dehydrogenation of indolines, tetrahydroquinazolines, and related N-heterocycles. The catalytically active species is presumably Au(0) nanoparticles.