190448-57-8 Usage
Description
EZETIMIBE PHENOXY GLUCURURONIDE is a glucuronide metabolite of Ezetimibe, which is an antihyperlipoproteinemic agent. It functions as a cholesterol absorption inhibitor and is characterized by its white solid appearance. EZETIMIBE PHENOXY GLUCURONIDE is highly hygroscopic, necessitating careful handling to maintain its stability and efficacy.
Uses
Used in Pharmaceutical Industry:
EZETIMIBE PHENOXY GLUCURURONIDE is used as a Phase-II metabolite for its role in cholesterol absorption inhibition. As a metabolite of Ezetimibe, it contributes to the overall efficacy of the drug in managing hyperlipoproteinemia, which is a condition characterized by elevated levels of lipoproteins in the blood. This application aids in the treatment and prevention of cardiovascular diseases by reducing the absorption of cholesterol and promoting overall cardiovascular health.
Used in Research and Development:
In the field of research and development, EZETIMIBE PHENOXY GLUCURURONIDE serves as a valuable compound for studying the metabolic pathways and pharmacokinetics of Ezetimibe. Understanding the behavior and effects of this metabolite can lead to the development of more effective drugs and therapies for managing cholesterol levels and related health conditions.
Used in Quality Control and Standardization:
EZETIMIBE PHENOXY GLUCURURONIDE is utilized in the quality control and standardization of pharmaceutical products containing Ezetimibe. As a specific metabolite, it can be used to ensure the purity, potency, and consistency of these products, thereby maintaining the safety and efficacy of the medications for patients.
Check Digit Verification of cas no
The CAS Registry Mumber 190448-57-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,0,4,4 and 8 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 190448-57:
(8*1)+(7*9)+(6*0)+(5*4)+(4*4)+(3*8)+(2*5)+(1*7)=148
148 % 10 = 8
So 190448-57-8 is a valid CAS Registry Number.
InChI:InChI=1/C30H29F2NO9/c31-17-5-1-15(2-6-17)22(34)14-13-21-23(33(28(21)38)19-9-7-18(32)8-10-19)16-3-11-20(12-4-16)41-30-26(37)24(35)25(36)27(42-30)29(39)40/h1-12,21-27,30,34-37H,13-14H2,(H,39,40)/t21-,22+,23-,24?,25-,26?,27?,30+/m1/s1
190448-57-8Relevant articles and documents
An in vitro assay for evaluation of small-molecule inhibitors of cholesterol absorption
Kvaerno, Lisbet,Ritter, Tobias,Werder, Moritz,Hauser, Helmut,Carreira, Erick M.
, p. 4653 - 4656 (2007/10/03)
Giving cholesterol the brush off: An intestinal brush border membrane vesicle assay has been devised for the convenient in vitro testing of small molecules for inhibition of cholesterol absorption. The assay was used to identify new nonhydrolyzable glycosides as potent cholesterol-absorption inhibitors and an oxazolidinone as an effective replacement of the β-lactam scaffold of ezetimibe (1).
