19050-67-0Relevant academic research and scientific papers
Aldehyde-specific quinazoline ring-closure for highly sensitive fluorescent and redox formaldehyde detection
Huang, Wei,Shen, Fuxing,Wu, Dayu
, p. 896 - 898 (2015)
Structurally tunable small signaling molecules have been specifically designed to probe-free formaldehyde concentrations as low as 0.1 ppm, establishing the utility of probing the exposure limit for safe human consumption according to the guidelines suggested by W.H.O. The substrate, 2-aminobenzoylhydrazide, fluorescent core skeleton was designed for the construction of diverse quinazoline compounds with combinatorial substituent-pending potentials via rapid condensation reactions with aldehyde groups. After identifying the fluorescent species by 1H NMR and X-ray crystallography, we demonstrate that the fluorescent emission is substituent dependent and that, by simple structural variation, the fluorescence can be tunable through controlling internal charge transfer (ICT) within a dye platform. Finally, by introducing more electron-rich ferrocene into the substrate to further undermine the ICT process, we demonstrate highly sensitive formaldehyde sensing through dual signal output, including fluorescence and redox potential.
Formation of 1,2-Dihydroquinazolin-4(3H)-ones. Reinvestigation of a Recently Reported 1,3,4-Benzotriazepine Synthesis
Fueloep, Ferenc,Simeonov, Mario,Pihlaja, Kalevi
, p. 531 - 538 (2007/10/02)
A recent paper (Bull.Chem.Soc.Jpn. 59, 1575/1986/) reported that the reactions of o-aminobenzoylhydrazine with benzylideneanilines lead to the formation of 1,3,4-benzotriazepin-5-one or 1-(o-benzylideneaminobenzoyl)-2-benzylidenehydrazines, depending on the substituents used.This is shown by the present paper to be incorrect.Depending on the proportions of the reagents, the above reactions lead to 1-(o-aminobenzoyl)-2-benzylidenehydrazines (7) or 2-aryl-3-benzylideneamino-1,2-dihydroquinazolin-4(3H)-ones (8).
